You may know that Graves’ disease is a type of autoimmune disorder that causes the thyroid gland to produce too much thyroid hormone (hyperthyroidism). But did you know that Graves’ disease is shockingly 5 to 10 times more prevalent in men than in women? It sometimes causes eye-bulging, and yet even with that fairly hallmark symptom, it sneaks under the radar of some physicians. A goiter can accompany the disorder, depending on the stage. Today, I’ll tell you about a natural breakthrough that could help which costs only pennies per day!
Graves’ disease is also known as Toxic Diffuse Goiter. As mentioned above, it’s the opposite of hypothyroidism, which is a topic I often write about. Graves’ disease takes its name after the doctor who described it for the first time in 1835, Dr. Robert J. Graves. It’s actually quite a common condition, affecting more than 3 million individuals in the US and about 10 million people worldwide.
If you have this condition, it causes your immune system to produce antibodies that stimulate the thyroid gland to make more thyroid hormone than you need. You fall out of balance. The exact cause of why the immune system works in this bizarre fashion is unknown, but researchers have identified some contributing genetic and environmental factors. It usually runs in families.
You probably already know that vitamin D, commonly referred to as the “sunshine vitamin”, is essential for keeping your bones healthy. But emerging research in the past few years has revealed that vitamin D is needed in most organ systems in order for you to thrive.
A deficiency of vitamin D has been associated with many other autoimmune diseases such as Rheumatoid Arthritis (RA), Multiple Sclerosis (MS) and Systemic Lupus Erythematosus (SLE). You can tell where I’m going with this, right? To Graves’ disease.
And in fact, researchers have investigated the correlation between Graves’ disease and low vitamin D levels. There are some interesting correlations between the sunshine vitamin and Graves’.
In a study published in Endocrine Journal (2012), scientists examined vitamin D levels in 26 women who had Graves’ disease. This data was compared with vitamin D levels in 46 healthy (non-afflicted) women who had normal thyroid function and no signs of Graves’. The vitamin D levels in women afflicted with Graves’ disease were considerably lower than the healthy participants. The difference in the vitamin D levels between the two groups was deemed “statistically significant,” which means that it is beyond a shadow of a doubt that low vitamin D levels are tied to Graves’ disease.
But one study doesn’t prove anything conclusive in my book. Let’s look at another.
There was another research study in which the levels of vitamin D in 208 Graves’ disease patients (146 women, 62 men) were assessed. The women were far more vitamin D deficient than the men (38% vs. 17%). To what shall we attribute this?
Perhaps women tend to avoid sun exposure and when they do lay in the sun, they’re more apt to use sunscreen as compared to men. Maybe men participate in more frequent outdoor activities without applying sunscreen. It’s just a thought. It could also be tied to hormonal factors like estrogen or testosterone.
There’s an interesting seasonal variation in vitamin D levels. As you would expect, the vitamin D levels were higher in summertime and relatively lower during wintertime. In winter months more than half the women experienced suppressed D levels.
I think the most worrisome part of the research, is that women in their 20s were found to have the lowest vitamin D levels. This has significant health implications, as women are expected to reach their maximum bone mass by the age of 30 and young women with low vitamin D levels are more likely to have lower bone mass and higher risk of osteoporosis in later life.
If low levels of vitamin D contribute to causing or exacerbating Graves’ disease, could improving vitamin D levels regulate thyroid metabolism? It’s an interesting question and one that researchers have wondered about themselves.
In 2014, researchers published an article in Clinical Medicine Insight about a woman in her 40s whose symptoms did improve after vitamin D supplementation! She had complained of heart palpitations for the prior three months and finally went in to see her doctor.
In this case study, her physical exam revealed an enlarged thyroid gland which is consistent with Graves’ disease. Lab tests checking for antibodies confirmed that she had Graves’ disease. Additionally, she had lower than optimal vitamin D levels. The patient was given a vitamin D supplement (cholecalciferol 4,000 IU) each day for six months. After that, she was given a prescription for 50,000 IU per month of a synthetic form of vitamin D… different than the more natural forms sold without prescription. Regardless, follow-up showed continual improvement in her mental and physical symptoms. Her improvement was confirmed with better thyroid hormone lab values as well as antibody reduction.
We don’t have thousands of people from a large-scale study, but in my humble opinion, we do have enough data here to make the case that D can support healthy antibody levels not only in Hashimoto’s, but also Graves’ disease. Why? Because we know that vitamin D is an immune-modulator. We know that it supports Th1 and Th2 immune functioning. We know it improves mood in people who feel gloomy and tearful.
Maintaining adequate vitamin D levels through sufficient sun exposure, healthy diet, and supplementation is crucial for keeping your body and mind healthy. And after reviewing the scientific literature on this topic, I think this could be supportive for people struggling with immune dysfunction, especially as it pertains to high levels of thyroid hormone or erratic, swinging levels. You can always ask your doctor if it’s right for you. Keep in mind that too much D will drive up levels of magnesium and calcium so keep your doses within a healthy range, don’t overdo it.