When it comes to anti-aging skincare, everyone wants results — fewer wrinkles, firmer skin, and a healthy glow — without the risks or downtime of injections. That’s why my Collagen Beauty Peptide Serum features Neodermyl®, an award-winning ingredient often referred to as the “needle-free filler.”
What is Neodermyl®?
Neodermyl is a clinically studied bioactive complex developed by Givaudan Active Beauty. It combines:
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Methyl-Glucoside-6-Phosphate (MG6P) – an energy molecule that reactivates aging fibroblasts (the skin’s collagen and elastin factories).
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Copper Lysinate/Prolinate – a bioavailable copper complex bound to the amino acids lysine and proline, which are critical building blocks for collagen and elastin synthesis.
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Glycerin and Water – to support skin hydration and ingredient delivery.
This unique combination doesn’t just “plump” the skin temporarily. It stimulates your skin’s own production of Collagen I, Collagen III, and elastin — the structural proteins that keep skin firm, smooth, and resilient.
Why Collagen & Elastin Decline Matters
Starting in our 20s, collagen production decreases by about 1% per year. Elastin, the protein responsible for skin’s snap and flexibility, also declines, leading to sagging and deep wrinkles. Fibroblasts — the cells that make these proteins — become sluggish, producing less structural support for the skin.
Neodermyl® addresses this issue head-on by delivering the exact nutrients and bioenergy fibroblasts need to “wake up” and get back to work.
Clinical Proof
In an independent in-vivo study, Neodermyl® increased skin firmness and thickness in just 15 days. The results showed:
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+6% dermal thickness in two weeks (nearly double the improvement from hyaluronic acid injections in a month)
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Significant reduction in wrinkle depth and volume
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Improved skin density and elasticity
These aren’t cosmetic cover-ups — they are structural changes in the skin’s extracellular matrix.
This is what Neodermyl does exactly:
Your skin is full of special cells called fibroblasts, which make the proteins that keep skin firm and elastic. When fibroblasts get old and slow down (senescent fibroblasts), they don’t make as much of these proteins. Normally, fibroblasts create pro-collagen I, the “unfinished” version of collagen I, which is the main protein that keeps skin strong, and collagen III, which makes skin more flexible and helps it heal. They also make tropoelastin, the early form of elastin, which gives skin its stretch and bounce. Together, collagen and elastin form the framework of healthy, youthful skin.
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Senescent fibroblasts – skin cells that have gotten old and slowed down, so they don’t make as much collagen or elastin anymore.
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Pro-Collagen I – the “unfinished” form of Collagen I that your body makes before it’s fully built.
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Collagen I – the most common type of collagen in your skin that keeps it firm and strong.
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Collagen III – a type of collagen that gives skin flexibility and helps it repair itself.
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Tropoelastin – the “starter” form of elastin before it’s finished and ready to work.
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Elastin – the stretchy protein in your skin that lets it snap back into place.
Why It’s in My Collagen Beauty Peptide Serum
My formula is designed for synergistic performance. Alongside Neodermyl®, it contains:
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SYN-COLL (Palmitoyl Tripeptide-5) – a biomimetic peptide that signals fibroblasts to boost collagen synthesis.
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Sodium Hyaluronate – a smaller molecule form of hyaluronic acid for deep hydration.
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Botanical oils & extracts – including avocado, jojoba, aloe, and rosemary, to nourish and protect the skin barrier.
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Boswellia Serrata & Rice Bran Extract – for antioxidant protection and anti-inflammatory benefits.
This combination means you’re not just delivering the message to make more collagen (via SYN-COLL), you’re also giving fibroblasts the raw materials and energy to do it (via Neodermyl®).
Your skin’s best days aren’t behind you — they’re just ahead.
How to Use Your Collagen Beauty Peptide Serum
For best results, apply 1–2 pumps to clean, dry skin, morning and evening. Smooth gently over the face, neck, and décolleté, allowing the serum to absorb fully before applying other products.
If you prefer, you can blend your serum with your favorite moisturizer in the palm of your hand before applying. This creates a luxurious, nutrient-rich emulsion that delivers all the collagen-boosting benefits in a silky, hydrating layer.
You may notice a subtle botanical aroma — a natural result of the serum’s high concentration of green tea extract and other plant actives. These phytonutrients are not masked with synthetic fragrance or chemicals, so you can be sure you’re experiencing their potency in its purest form.
The Takeaway
Neodermyl® has earned its reputation as a “needle-free filler” because it works where it matters: inside your skin, energizing fibroblasts to produce fresh collagen and elastin. When paired with the clinically proven SYN-COLL peptide and a base of hydrating, antioxidant-rich botanicals, you get a serum that supports healthier, younger-looking skin from the inside out — no injections required.
Suzy Cohen, has been a licensed pharmacist for over 30 years and believes the best approach to chronic illness is a combination of natural medicine and conventional. She founded her own dietary supplement company specializing in custom-formulas, some of which have patents. With a special focus on functional medicine, thyroid health and drug nutrient depletion, Suzy is the author of several related books including Thyroid Healthy, Drug Muggers, Diabetes Without Drugs, and a nationally syndicated column.
