M.B., Sanibel, Florida
Answer: Yes. Sometimes we grow tolerant to a drug so it seems like the magic effect is gone. Or a drug could remain fully potent, while the body continues to decline because underlying imbalances do not get corrected. Chronic illness often goes hand in hand with poor sleep, stress and pain so treating these will also help improve depression. Since Zoloft isn’t helping anymore, try 5-HTP, a natural over-the-counter antidepressant.