The medicine your doctor never told you about (but should have)

Low dose naltrexone or LDN is the prescription medication that every doctor has heard of, but never prescribes. Regular naltrexone (not low dose) is used for heroin addicts, alcoholics and opiate withdrawal. I think that’s why doctors don’t really think about it, it’s for people with drug addiction.  That said, the low dose version of the same drug has undeniable applications for autoimmune conditions, chronic infections and pain syndromes. Consider it an affordable adjunct especially because Remicade, Imuran, prednisone and other immune drugs come with hefty side effects and outrageous price tags.

LDN has two functions in your body:

1) It helps you tolerate your self.
2) Reduces inflammation in your nervous system.

Let’s start with number 1, tolerating yourself. Even if you can’t tolerate your annoying brother, you still need to tolerate yourself! I’m being facetious, but seriously, you must have the ability to tolerate your self, otherwise your immune cells attack your self. We call that an autoimmune disorder, and it means you’ve lost self tolerance. Think of rheumatoid, Hashimoto’s, ulcerative colitis, Crohn’s, and others. When you take LDN, you better tolerate “self.” It happens because LDN turns on “T regulatory” cells and those smack down your immune system. So yeah, forget everyone else, tolerate your self first, if you want to have good health. Your T reg cells help you do that.

T reg cells have their own job which is to make sure that inflammatory chemicals are secreted appropriately to help you when injured, and then to stop that inflammation after you’re healed. If you don’t stop production of inflammatory chemicals (termed cytokines), then your body starts attacking everything in sight, pollen, dander, mold, dust mites (then you lose self tolerance) now it’s attacking your thyroid, your joints, adrenals, heart or myelin sheath around nerve endings. Again, LDN acts like a referee and blows the whistle on this attack.

Now, number 2 on my list is how LDN reduces inflammation in your nervous system. This is a huge advantage if you suffer with thyroid disease, depression, fibromyalgia, chronic fatigue, Lyme or neuropathic pain. Several papers written on this topic have shown that LDN blocks microglia in your central nervous system. These microglia are just immune cells in your brain and spinal cord that, when hyperactive, produce pain-causing chemicals, fatigue, unstable mood, insomnia and cognitive dysfunction. To your microglia, LDN feels like a cold compress does to a sunburn.

If you have any of the following conditions, I urge you to ask your physician if you can try some LDN for a few months at a very low dose, and gauge response:

  • Rheumatoid arthritis
  • Crohn’s disease
  • Celiac
  • Hashimoto’s thyroiditis
  • Graves’ hyperthyroidism
  • Multiple Sclerosis
  • Lupus (SLE systemic lupus erethematosus)
  • Sjogren’s
  • asthma
  • Raynaud’s
  • Eczema
  • Vitiligo
  • Ménière’s disease
  • Parkinson’s disease.

LDN works by blocking receptors on your cells that allow natural endorphins in. Endorphins are compounds you make when you feel good, eat chocolate, experience a runner’s high or have sex. Endorphins increase your pain threshold. You want them inside the cell. With LDN blocking the cells, they become short on endorphins and send a chemical signal to your brain to say, “Hey, crank out more endorphins because I have none!”  Your body generates more endorphins in response to the perceived deficiency.

You probably get more endorphins in that moment, than a Black Friday sale at DSW! Emerging studies regarding dosage suggest that lower is better, such as 1 to 3mg at bedtime. Side effects are minimal and may include vivid dreaming or sleep disturbance which improves if you reduce dose or take during the day. As a pharmacist, this medicine is one of my all-time favorite drugs because it has few if any serious side effects. Remember, it is a prescription so your doctor has to call it in to a compounding pharmacy, I get notes all the time from irritated people who say “My doctor called Walnuts pharmacy and they said they don’t have it” or “Have Suzy call me and explain how to get 1.5mg out of a 50mg tablet!”
Right, lol, that would be a big mistake! I’m not recommending you ever have a conventional pharmacy attempt to make this for you out of their 50mg tablets (standard for people using it for narcotic withdrawal) or from their injectable suspensions. No, I’m referring to the type of LOW DOSE naltrexone that is mixed up at professional, inspected awesome compounding pharmacies every day!

LDN is compounded all the time, every day at pharmacies who specialize in making teeny weeny doses of it (and those are the types of doses you want since you are a not a crack addict!)

Of course retail pharmacies don’t have it! I said this has to be called into a compounding pharmacy, so look in your phone book (do they even print those anymore?) or Google it online.  Do like I do, and ask Siri she’ll find you a compounding pharmacy. I just tried it on my iPhone and she found 3 of them near Denver and Boulder.  Many compounding pharmacies can ship LDN to you home, so if there isn’t one in your city don’t give up. LDN is shipped all over the country, every day!
That’s a great site with more answers to all your questions since I can’t answer all of you personally. It’s impossible for me to teach one doctor at a time as this will eat up hours of my day, each day. Please understand I get hundreds of emails a day, into the thousands if you count all the different places people can ‘talk’ to me via social media, my newspapers, and so forth.

The dosage starts around 1.5mg taken once at bedtime. Vivid dreams can occur as you titrate upwards to 3 or 4.5mg.  While some disagree with me, I feel that taking it in the daytime is okay if you can’t tolerate it at night, like … if you get nightmares or insomnia. Then in that case I would definitely take it in the morning, and also I recommend you stay at the lower dose, like approximately 1.5 milligrams.




  1. Stephen Goodwin January 4, 2015 at 10:04 pm - Reply

    LDN for psoriasis?!

  2. Lauren Royal January 4, 2015 at 10:14 pm - Reply

    Thanks for spreading the word, Suzy! I have Hashimoto’s, celiac, and Crohn’s, and I take Humira for the latter. For many years, because the Humira (and before that, Remicade) knocked down my immune system, I had a constant cold and a very hard time getting over anything else I caught. I was *always* sick! About five years ago, I talked my GI doc into prescribing LDN, which he thought wouldn’t help but also figured couldn’t hurt me, so he humored me to prove me wrong. Well, guess what? Now I am so much healthier–even on Humira, I now get over colds and other illnesses like a normal human. And he is a believer–he went from being a skeptic to prescribing LDN for many of his other patients. It’s not covered by my insurance, but it’s cheap and well worth the price for much better health. I encourage anyone with autoimmune issues to give it a try.

  3. Joya Skye January 4, 2015 at 10:21 pm - Reply

    Dear Suzy, I recently was informed about the use of LDN in the UK specifically for CFS. They are giving it in the morning and at much higher doses. Well, not much higher, but at 10 or 12mg. According to the blog it has really good results with CFS. I am now taking 4.5mg in the morning and planning to take 6mg soon. Do you know anything about this? I would love to know what you think. warmly, js

  4. Shirley Jacobson January 4, 2015 at 10:25 pm - Reply

    Add Lyme and Sarcoidosis to your list. My naturopath put me on LDN but it seems to keep me awake so I start and stop it without much evidence of relief.

  5. Dan Beller January 4, 2015 at 10:27 pm - Reply

    What do you recommend to reduce inflammation which causes my joints and muscles to ache, especially in my lower back? Thanks, Dan.

  6. MONICA C. DUNKLEY January 4, 2015 at 10:27 pm - Reply

    Dear Dr. Cohen,
    Thank you for making us aware of how much we should bee tuned in to our own bodies!
    I will research L.D.N.
    Please continue with your education of the public.
    Monica Dunkley

  7. Linda January 4, 2015 at 10:36 pm - Reply

    Hi Suzy,

    I am a Hashimoto’s thyroid sufferer with celiac disease and 2 MTHFR mutations. I have followed a clean diet, Paleo, gluten-free, dairy, grain-free, and soy free. I take Dr. Lynch’s supplements for MTHFR. I have tried every different thyroid medicine out there. None of this has helped me. For nearly 12 years, I have suffered with increasing painful leg and foot cramps and some other fibromyalgia-like pain in other areas. Recently, I read your article for the upcoming Pain Relief Project on Hashimoto’s and pain. I have been considering LDN for some time but afraid of the Candida it might cause, which I have had in the past. What can you suggest I try? I do not want to go back on Lyrica because of its side effects and semi-effectiveness, but the pain has restricted my mobility and quality of life. I have followed your seminars and newsletters and think you are wonderful and informative.

    • Suzy Cohen January 7, 2015 at 11:50 pm - Reply

      This is complex, I’m not a doctor. I don’t know if CoQ10 (ubiquinol) or low dose creatine would even help but you can ask your doctor about those. Have you tried physical therapy, yoga (stretching), magnesium? Have you had all your snps tested? DO you drink wine at night, or coffee during the day? There is a drug mugging effect with those which can steal nutrients that cause you to cramp up.
      Kavinace is a nice way to increase GABA, and it’s non-prescription. Ask doc if it’s right for you b/c it makes you drowsy and increases GABA.Can’t be taken with certain medications either. Good luck

  8. c January 4, 2015 at 10:41 pm - Reply

    Is this helpful for alopecia areata or for lichen schlerosis?

  9. Nadia blahut January 4, 2015 at 10:51 pm - Reply

    Is there anything natural ( not prescription) that mimics NDL? Don’t care to go to doctor if I can at all help it.

  10. DavidRN January 4, 2015 at 10:57 pm - Reply

    Thanks for an LDN intro, I am just starting my 4th month. I stopped my Embrel and Methotrexate (for RA) in the first week of Sept. Unfortunately still having some discomfort, but went with the common dosing of Prednisone(PRN) at less than 10mg/Day. (Below 10mg QD is believed to NOT have an ImmunoSuppressant effect). I checked my CRP, went from 2 to 15 at 2 month point. Hope as LDN starts to work, I can reduce the Prednisone, this week at 5mg at bed, 2.5 in AM.Hope you can write more about LDN, or maybe interview Skip Lentz.

  11. Linda January 4, 2015 at 10:58 pm - Reply

    Could you please elaborate on whether LDN would need to be taken indefinitely if it has a good effect? Can you stop after a time or will symptoms return or potentially worsen if you stop?
    (Thanks for all the useful information so far. I always make the time to read the articles…any suggestions on how to make a day longer! Now that too would also be useful!)
    Cheers from Australia!

  12. Becky January 4, 2015 at 11:03 pm - Reply

    Thanks for the info Suzy. Would this work for fibromyalgia, ADD, or chronic pelvic pain as well?

  13. Bonnie Scot January 4, 2015 at 11:08 pm - Reply

    Dear Suzy,

    Please add fibromyalgia, myalgic encephalomyelits, and chronic fatigue syndrome to the list of conditions that improve with LDN. As a lifelong patient I have achieved the best quality of life ever with LDN. Over a period of 2 years I have slowly titrated the dose from 1 mg to 6 mg per night. This gives astonishing relief from allodynia and hyperalgesia. Lowering the dose brings back significant pain.

    Thanks for your commitment to improving health,


  14. helene January 4, 2015 at 11:18 pm - Reply

    medicaid would never pay for a compounding pharmacy, is my understanding 🙁

  15. Judy January 4, 2015 at 11:23 pm - Reply

    I took LDN for about 2 wks and had the most terrible reaction to it with violent skeletal cramps 24/7 that could not be relieved. I have Hashimoto’s as well as many allergies, NCGS, Raynaud’s, fibromyalgia & chronic fatigue symptoms. My practitioner thought this would really be helpful but I never felt so awful as when I was taking it. It may work for some but is not tolerated by all.

    • Suzy Cohen January 7, 2015 at 11:38 pm - Reply

      It has virtually no side effects so that is bizarre.
      Are you sure it was not something else, or the way it was compounded for you? Maybe they gave you the wrong medicine?
      It is a compound.
      In 20 years, I’ve never heard of that. I do know that people who combine it with alcohol or opiates have a severe reaction, and in fact that is the point of high dose naltrexone,it’s for addiction. But low dose should not do that.
      Regardless, thank you for posting your experience, in case others have a reaction, it is good that we are all informed of pros and cons and that is why I opened my forum below my blogs.

  16. susan grosser January 4, 2015 at 11:28 pm - Reply

    Since being diagnosed with Graves disease 5 years ago,I have been on a Methimozole regimen ,after being seen by 5 endos.

    I honestly thought that I could reverse it doing all the right things.
    Supplementation.Meditation.Juicing.Earthing.Dr.Jonathan Wrights protocol.
    Nada helped.Now I have been told by another,new endo that I will need surgery for nodules after the biopsies in case it is cancer
    I asked every one of them for ldn….”No way!It is not proven”!
    What is wrong with the medical society that cannot give honest side effects and future predictions?I would have had RAI! Now, I am furious with all of them.It is a money machine.Nothing more.

    • Suzy Cohen January 7, 2015 at 11:34 pm - Reply

      Hi Susan
      Have you purchased a copy of my book Thyroid Healthy?
      I have a chapter on Graves’ disease in there, with hard-to-find information that can help you, and it’s much different than Jonathan’s information. Check it out. Click on my “shop” tab at the top of this site, and then click on the book image.

  17. Sims ahmed January 4, 2015 at 11:35 pm - Reply

    Is LDN an IV that patients inject themselves.
    How much research has been done on LDN for the benefit of autoimmune disorders.

    • Suzy Cohen January 7, 2015 at 11:33 pm - Reply

      It’s a capsule, not an IV. You take it by mouth.

  18. Purvin January 4, 2015 at 11:55 pm - Reply

    Hi Suzy: much appreciate all the info that you are sharing so willingly. i had a question: what do you recommend for parkinson’s to stop or control the tremors? my mother has parkinson’s and she has a lot of tremors. she is not on any drugs, but does take many supplements. she is worried about side effects of prescribed medication, so if you have experience with something that is not harmful, or a supplement that would support her, that would be great.
    thank you so much and God Bless you for all the help you are providing to so many of us.

  19. Jem January 4, 2015 at 11:58 pm - Reply

    Suzy, I love your emails and newsletters and look forward to seeing what else is new. I am 77 yrs old and have been diagnosed with Polymyalgia Rheumatia. My Rheumatologist prescribed Prednisone for me. Prednisone does help with my pain but I dislike taking it. My question – do you think LDN would help me? I would like to know before I mention it to my doctor. Thank you in advance for your response.

  20. Aach January 5, 2015 at 12:20 am - Reply

    I just took my first LDN last night and I couldn’t sleep. After reading what u said abt taking it earlier I took my today pill LDN at 6:30 PM. I do feel weird……

  21. Linda January 5, 2015 at 12:22 am - Reply

    Need help here!!! Thank you for your books, the upcoming Summit, and your concern for the silent killer taking many of us. We have been everywhere we can get to, spent all of our money on doctors and meds, supplements, herbs. Because of pain, our brains just can’t make sense of it anymore….no energy to get up. Been begging for help for 18 years – knew something was happening…”Tried my best to explain it to them” – IBS, then fibro, then hashimotos thyroiditis, finally in Sept breast cancer surgery – and the fire keeps raging!!! H E L P ! ! !

  22. Rebecca Hill January 5, 2015 at 12:32 am - Reply

    I am interested in LDN but have heard from many sources that if one is on one of my drugs I take for my muscle pain called tramadol, it will make you horribly ill.
    So that scared me away from it. My doctor was going to rx it, but he didn’t even know that.
    So what do you think about taking it with Tramadol?
    Rebecca Hill

    • Suzy Cohen January 7, 2015 at 11:32 pm - Reply

      Hi Rebecca
      Because LDN blocks opioid receptors throughout the body for several hours, if you take
      narcotic medication such as Ultram (tramadol), morphine, Percocet (oxycodone) Duragesic patch (fentanyl) or codeine, you
      should not take LDN until your medicine is completely out of the system which may take a week or two depending which drug you’re on.
      It negates the action of these drugs.

  23. Linds January 5, 2015 at 12:34 am - Reply

    Will LDN be detected on standard employment drug screens??? Due to the nature of what the drug was originally marketed for, it could raise a red flag. I am a Lyme sufferer, with all kinds of problems with joints, etc and am very interested in trying this out…. but it could pose a problem as I take drug tests regularly.. PLease advise.

    • Suzy Cohen January 7, 2015 at 11:27 pm - Reply

      LDN is not an opiate, it is not something that employment drug screens look for. It’s not a red flag.

  24. Nicole January 5, 2015 at 12:42 am - Reply

    I have been on LDN since July and my thyroid numbers are improving! I have 2 questions though:

    1.) How does one truly know if LDN is helping? Is there any other testing that can be done to measure its effectiveness?

    2.) What are your thoughts on LDN for teenagers who have auto-immune issues and test Igenex positive for Lyme?

  25. Val January 5, 2015 at 12:45 am - Reply

    I take synthroid and I really get hot flashes from it. Is there any meds that don’t cause the hot flashes?

  26. Bonney Bentley January 5, 2015 at 1:13 am - Reply

    I would love to try low dose LDN, but I know for a fact if I ask my Dr. for this he will not give it to me. So what do you think I should do.

  27. Lisa Bloomquist January 5, 2015 at 1:46 am - Reply

    Thanks for this great post, Suzy! A lot of “floxies” (people suffering from an adverse reaction to cipro, levaquin, avelox or other fluoroquinolone antibiotic) have reported feeling relief from many symptoms with LDN. Fluoroquinolone toxicity looks and feels a lot like an autoimmune disease. It’s good to know that it’s an effective treatment for autoimmune diseases – and adverse drug reactions that look a lot like autoimmune diseases.

  28. Jenny Verrill January 5, 2015 at 1:59 am - Reply
  29. Scott Mery January 5, 2015 at 2:09 am - Reply

    After reading your article I sent an e-mail to my doctor that I want to try the LDN. I have MS, 35years, right now on Tecfidera but I want to try the LDN if he will prescribe it for me. I’ve known about LDN for a few years but never thought about using it until your letter and I did some more digging about it for MS. So thanks for your letter and I am grateful that I am on your e-mail list.

  30. Pat January 5, 2015 at 2:11 am - Reply

    I have environmental and food allergies. Are you saying LDN would be effective for these?

  31. Annette January 5, 2015 at 2:16 am - Reply

    Thank you for getting this word out. I have taken LDN for about a year for Collagenous Colitis…saved my life. I was dropping weight at a scary fast pace despite changes in my diet and lifestyle. And I was on some wonderful supplements per my ND. All were helping but nothing as well as the LDN.

  32. Dale Almond January 5, 2015 at 2:25 am - Reply

    I tried LDN a number of years ago for neuropathic pain and autoimmune problems resulting from a long history of undiagnosed celiac disease. No matter how low the dose went – down to .5 mg – I suffered from extreme nausea as a side effect, making it completely intolerable. Why do you think this happened? Are there certain people for whom it is contraindicated? I have heterozygous MTHFR C677T – could this be a factor?

  33. Bonnie January 5, 2015 at 2:29 am - Reply

    Hi Susie,
    Thanks for all the great information you send. How you help all of us!

    I just have a question about the LDN response when the huge flow of endorphins comes around in response to the cells’ signal to the brain – does LDN get “overwhelmed” and therefore lets the endorphins into the cells instead of blocking the receptors as it had done originally? Thanks. I love finding out how these mechanisms work & since I am a visual learner I can picture them in my mind and remember better.

  34. louise Enderlin January 5, 2015 at 2:41 am - Reply

    I do not have pain, but may have menier’s disease? due to the dizzy spells I get when I go to sleep as I lay down and try to get up again @ night. I try to keep the room dark and it is quite here for the most part. I do not drink and have been G/F now for 7 going on 8 years. I still have out breaks some and I also have allergies to metal as I have taken off my earrings and stopped brushing with the electrical toothbrush and it seems to make a difference.
    ANY ideas ir I need to take this? Since my move I have not found a doctor yet and my dentist passed away I was in shock way too young to go so soon! A great man! always made me smile
    Louise Enderlin
    [email protected]

  35. Perry January 5, 2015 at 3:02 am - Reply

    After a couple decades of extreme stress, my thyroid and adrenals are running very low. Autoimmune reactions (antibodies elevated). Basically Hashimoto’s. Plus, I’ve always been super sensitive and overreactive to just about every goitrogen, carb, prebiotic, probiotic, fermentation, alcohol, honey, additive, bad combinations, food in general, metal, dustmites, plastic, supplement, perfume, drug, chemical, tag/seams in clothing, shoelaces too tight, clutter, EMF, voice inflection, asymmetry, stressor, calmers, WHATEVER is going on. I seem to just over-“sense” anything. As such, I’m honestly just afraid to try another actual drug, even if it is a “low” dose. They have almost never helped me and almost always toxified me further. (38-year old 5’7′ chronically underweight male).

    Comments Suzy? (or anyone else with a similar situation.)

  36. Cindy S January 5, 2015 at 3:21 am - Reply

    I can’t thank you enough for this post! I was started on LDN 6mg at night and told it must be taken at night because it causes drowsiness. Not so for me!! I lay awake all night! Reading here that taking it in the daytime really is “okay” gives me renewed hope that I can actually benefit from LDN. I am so appreciative of all your posts well as your Thyroid Summit and your valuable contributions to other summits over the past year. Thankyou, Suzy!

    • Suzy Cohen January 7, 2015 at 11:15 pm - Reply

      Awesome Cindy. Let me know how you do on it during the day.

  37. Tanya January 5, 2015 at 3:32 am - Reply

    Would it help someone with lesions from anti-cardiolipid antibodies?

  38. Debbie January 5, 2015 at 4:00 am - Reply

    Hi Suzy
    My husband is a pediatrician and I am a nutrition counselor in Boulder,CO. We spent a lot of time this past year researching LDN and are now using it in our practice–with great results so far! I am wondering if you can point me to the research you mention on lower doses of 1-3mg. The research we have seen so far has pointed to 4.5mg typically. We are personally dosing by body weight, which is commonly done in pediatrics. Thank you! Debbie Steinbock

    • Suzy Cohen January 7, 2015 at 11:08 pm - Reply

      Hi Debbie
      I think I live 10 miles from you 😉
      I can’t recall where I learned that, it was not off a clinical trial, it may have been a roundtable or a break out session at IFM, or A4M, or maybe it was during a conversation with an LDN-prescribing doctor. But I noticed the same thing anecdotally with 5 people who I know for a fact took it, and all of them said they got up to the 4.5 and had to back down after a week due to symptoms. So I would just use lower dosages and if there is no clinical response, or reduction in systemic inflammatory markers, or increase in CD4 counts, etc… you can go up from there.

  39. Liz January 5, 2015 at 4:06 am - Reply

    You mentioned fibromyalgia early in your article, but did not list it in your list of conditions LDN should be considered for. Also, are there any things to look out for while taking LDN? Drug or alcohol interactions?
    Thanks for your time.

  40. Gayla McClellan January 5, 2015 at 4:49 am - Reply

    I cannot find a doctor in Oklahoma that will write a script for this medication, they act as if I want narcotics. I finally just gave up its embarrassing! Any suggestions? Gayla

    • Suzy Cohen January 7, 2015 at 11:02 pm - Reply

      OMG! They should be embarrassed, not you.
      You’re clearly more educated on the topic than they are!
      Call a compounding pharmacy within your state, or in Colorado and ask who the prescribing physicians are that order it in OK.
      Someone does, trust me.

    • Mimi March 30, 2016 at 4:56 pm - Reply

      Linda Lea Clinic in OKC. She just put me on this med. I can’t believe it! Only on day two and my pain levels are WAY down!

  41. Julie January 5, 2015 at 6:20 am - Reply

    I take 3 MG of LDN. I had cancer in 2013 and asked my integrative md in NYC for a prescription of LDN. He started me off with 4.5 mg, that was to high my my pulse went way to high.I have hashimoto’s for over 1 1/2 years now so I take it for these 2 reasons. When I lie down to go to sleep recently last 2 months my body starts to tremble .I don’t know why and I have been to 3 integrative md in NYC doctors. Only one Integrative md in NYC I went to ever prescribed LDN to his patients. I have heard taking LDN in the morning is fruitless. But your web page says its ok to take it in the morning is this true. I planning to call Dr. Skip a Pharmacy in Florida and ask them very soon they seem to know a lot about LDN.

    • Suzy Cohen January 7, 2015 at 11:00 pm - Reply

      Hi Julie
      Do you have high homocysteine by chance? I have a thought.
      Skip… yes, tell him I said hi. He’s a master at making LDN! Good man 🙂

  42. Lynne January 5, 2015 at 6:27 am - Reply

    What do you think of this comment from Wikipedia on LDN:

    Skeptic Steven Novella of the Yale University School of Medicine disputed these claims as unsupported by rigorous clinical research, calling many applications pseudoscientific. He further argues that the claim that low-dose naltrexone as an effective treatment for both immune dysfunction and autoimmune diseases is contradictory, and that improving the immune system could make the autoimmune disease worse.[3] Novella also writes that claims of treating a wide range of diseases with different etiologies should be a red flag

    • Suzy Cohen January 7, 2015 at 10:59 pm - Reply

      Hi Lynee
      What do I think?
      I think he’s entitled to say what he wants.
      I think there’s indisputable evidence from people who say it changed their life.
      I think it’s worth a try if you are suffering. Why choose suffering when you can try raising endorphins (which we make naturally).
      I think if he were ever in a sick or vulnerable position, and someone offered it to him as a potential treatment, he’d take it 😉

  43. Ginny Dudek January 5, 2015 at 12:09 pm - Reply

    LDN has been my wonder drug for Lyme for 4+ years.

    It’s rare for people to have nightmares, but vivid dreams are common for a few weeks. Sleep feels light, for people who haven’t remembered dreams in a while. Light sleep after a REM cycle can be misinterpreted as insomnia. Learning sleep hygiene to get back to sleep can help.

    • Suzy Cohen January 7, 2015 at 10:57 pm - Reply

      Ginny that is wonderful! I’m grateful to you for taking a moment out of your busy day just to let others know about your success, and how something helped with Lyme. It is such a difficult infection to treat, and so giving others hope like this is sweet of you.

  44. Jennifer January 5, 2015 at 1:15 pm - Reply

    Thank you again for another article that came to me at the exact time I needed it. I have been looking for something to take for Lyme Disease symptoms and LDN keeps coming up as helpful. You explain it in an easy to understand way that will help me present it to my doctor in a couple of days. Thank you so much!!!

    • Suzy Cohen January 7, 2015 at 10:56 pm - Reply

      Hi Jennifer 🙂
      Glad I am in sync with you.
      Sam has Lyme, my hubby. He takes this on and off. I think he does better on it. Keep me posted on YOUR progress okay?

  45. Diana January 5, 2015 at 1:27 pm - Reply


    thank you for a very easy to understand explanation of how LDN works :).

    I was wondering though, what if the reason that your body keeps on attacking is that you still have an infectious pathogen that is active, and not the immune system attacking itself for no reason?

    I had Hashimotos, and a lot of parasites, when they were treated with the proper anti-parasite medications, my hashimotos cleared..I think LDN seems like a great option for pain relief, but Im concerned it might lower the immune system response when one has chronic parasite infections, which might not be great? .

    What do you think? Can one take it and be sure it definitely wont weaken the immune system in a not good way at all when it needs to combat an infection?

    // Diana

    • Suzy Cohen January 7, 2015 at 10:54 pm - Reply

      Hi Diana
      Thank you for such an excellent question.
      It is hard for me to know what is right for everyone. That said, I think most people know that my husband Sam has chronic Lyme disease from a tick bite. He takes LDN sometimes, and he’s off it sometimes. We never notice that he gets worse on it. In fact, he probably does better b/c the mechanism of action is such that his own immune system works better. I would think it’s fine to try just my personal opinion. You’ll know if you feel better within a few weeks, and if you start to get worse than you know that too. Information is power. Beats struggling. See what your doctor thinks though, because that’s who has to decide ultimately (along with you).

  46. philip goldman January 5, 2015 at 1:29 pm - Reply


  47. Sue January 5, 2015 at 1:52 pm - Reply

    Would this also work for sarcoidosis?

  48. Nancy January 5, 2015 at 2:22 pm - Reply

    Very interesting.I have terrible pain

    • Suzy Cohen January 7, 2015 at 10:51 pm - Reply

      Hang on Nancy, and you should sign up for free, so you can tune into the Pain Relief Project.

  49. Debby January 5, 2015 at 2:36 pm - Reply

    I would like to know what type of doctor would prescribe LDN? My endo just looks at me when I tell him I’m tired or problems with dry eye!

  50. UselessUnice January 5, 2015 at 4:38 pm - Reply

    Comment regarding one exception to this excellent recommendation. I’m a recovered alcoholic and former drug addict. As such, I regularly work with other active alcoholics, and addicts, and those still ‘recovering’ from their illnesses. A few such people actually had doctors who DID suggest this method of treatment for their ailments. Of the four people who took the advice of their trusted doctor, three of them became hopelessly kicked back into their respective addictions and ultimately surrendered their lives to them. These lives could have been saved with continued practice of seeking ease & comfort from an increasing spiritual practice coupled with actions for helping meet others’ needs. Instead, they ‘chose’ to follow the advice of well-meaning, yet uneducated doctors. They ‘chose’ immediate physical comfort over saving their physical lives, healing their mental lives & enhancing their spiritual lives. While these medications are helpful and successful in some people, for a small minority, they are lethal poison. In a culture promoting pharmaceuticals, it’s important to remember that some illnesses, especially those which involve bodily illness & are rooted in spiritual or mental illness, must be treated completely by treating body, mind and spirit.

  51. Joann January 5, 2015 at 4:44 pm - Reply

    You should probably mention that if you have excess candida this product won’t work for you.

    The fix for that isn’t as simple as taking a pill.

    • Dawn January 24, 2015 at 8:55 am - Reply

      I have been worried about possiblilty of candida. How would I know if it didn’t work because I had candida? Or another reason? How would I treat the candida with adrenal insufficiency (the azole type drugs knock the legs from under me).
      I am currently in my first week of ldn

  52. Randy January 5, 2015 at 6:10 pm - Reply

    Would this possibly aid in the relief of tinnitus?

  53. SunnySky January 5, 2015 at 6:56 pm - Reply

    I started on LDN a week ago! Not sure of the starting dose and for how long and when to increase it. Currently prescribed 1.5 mg. This is for my MS. Also found conflicting info on whether or not to stop the weekly Avonex (beta-interferon). I was diagnosed with MS in 1990; using Avonex since 1998 and sure would like to stop, if that makes sense. Had a bad flare Spring 2014 that took my dominant hand and arm for 1.5 month’s. Tons better now, but still not 100% (dexterity & strength).

    Dr also prescribed estriol, but it’s 2 mg. Again, I’m not sure I’m getting the full benefit if the dose is too low for either the estriol or LDN. Thankful, though, my Dr is willing. :).

    • Tracy January 13, 2015 at 6:02 am - Reply

      Dr. Pompa coached me. My symptoms never stopped bothering me until I changed my diet. After 3 years of changing, my symptoms stopped so stop the Avonex. Are you off processed foods? Have increased your good fats?
      Chiropractic adjustments are important also. Today I am detoxing Heavy Metals. Do you have silver fillings. Find a good dentist to remove them carefully. Today I feel fantastic! Praying you can make changes. Best Wishes. Tracy

    • Amanda February 3, 2015 at 11:54 pm - Reply

      I take LDN, and there’s a Yahoo group that helps with questions and concerns. I encourage you to join.

    • Thomas Handy February 25, 2015 at 8:48 am - Reply

      I took avonex for a year, and ldn too, the avonex made the numbness in my legs worse after every injection, I took ldn too and still do, its recommended by numerous
      ldn sites not to take the disease modifying drugs when taking ldn, but there is no
      `research supporting it..

  54. DIANA SHELL January 5, 2015 at 8:24 pm - Reply


    I gave them information, printed out stuff, sent all kinds of info and NOPE. do you know anyone in Oklahoma that will prescribe it????

    Please help

    • Amy January 8, 2015 at 9:05 pm - Reply

      Diane, I am on LDN, and I was able to get a prescription thanks to a good friend who keeps a list of doctors all over the world that will write prescriptions for LDN. I used a doctor that was able to have a telephone interview, as she is in Seattle, but I am in New Hampshire. Please write Crystal Nason at [email protected], and tell her where you live, and she will email you back with the names of doctors that you can see in person or have a telephone interview, and approximately how much they will charge. LDN is great because it normalizes the immune system, and has helped me and my MS. Blessings! 🙂

    • Bryan J Treacy MD January 8, 2015 at 9:57 pm - Reply

      Ms Shell:

      I have a protocol that I follow for management of these types of disorders. Traditional treatments do not help everyone and I have specialized in treating these types of conditions for many years. Low dose naltrexone is an acceptable treatment for these chronic conditions and can be utilized in conjunction with maximizing sleep patterns, hormones, immunity, nutrition and motion with good results usually within four months.
      We would be happy to see you at Women’s Ultimate Health Care in Oklahoma City. Phone number is 405-684-1477

      Bryan J Treacy MD

    • J. Sandefer January 24, 2015 at 1:19 am - Reply

      I don’t know where you’re located in Oklahoma, but you might try this pharmacy if you are in/around Norman…I went to HS school with the owner, Ken.

      Ken’s Discount Pharmacy
      Leader Drug Store
      808 North Porter Avenue
      Norman, OK 73071
      Phone: (405) 321-1445

      I just started using ultra-low dose LDN (1 mg capsule) for an autoimmune disorder 8 days ago and had to have it made at a compounding pharmacy because the FDA approved dosage (capsule) is 50 mg. The prescribing doctor talked directly to the lead pharmacist at Duran’s Central Pharmacy in Albuquerque, NM and explained the reason for the low dose. The pharmacist offered that she had compounded this medication for about a dozen patients having varying types of autoimmune disorders and was very familiar with it. I explained to her that my Mitochondrial Disease, peripheral neuropathy, daily dizziness and tiredness have totally derailed my quality of life for the past decade and I’ve had virtually no relief. She was optimistic the LDN would prove worthwhile, but it might take a few weeks or even a couple of months.
      I haven’t had any side effects to date and will titrate up to 2 mg per day a week from today. The doctor/pharmacist told me the typical long-term dosage for off-label issues is usually 3-4 mg per day. I’ll pay close attention to my symptoms and any side effects and may eventually reach this dosage level if necessary.
      Best of luck in getting your symptoms under control.

    • Jenny Tierney April 9, 2015 at 6:46 pm - Reply

      Dr. Grace Gallardo in OKC will prescribe it. She is a pain management dr. Hope this helps.

    • Mimi March 30, 2016 at 5:35 pm - Reply

      Linda Lea Clinic in OKC. If you aren’t near them, maybe they can tell you the name of someone near you who can prescribe it.

  55. Dianne January 5, 2015 at 8:59 pm - Reply

    Thank you so much for getting the word out on this very helpful drug of LDN. I am always so happy to see any articles about it. This was suggested to me by a doctor for peripheral neuropathy in my feet which was so miserable (not diabetic – cause unknown) and it has changed my life so much. I wish more doctors knew about this. I had asked one very well known doctor about it. He asked me “what is it”. I started to explain. He said he had never heard about it and “don’t take it”. Glad I didn’t take his advice. I also have Hashimoto’s and it has helped tremendously. My husband will be starting it shortly for just diagnosed Parkinson’s. I know the reason most docs don’t know about this drug is that there is no value to the pharmaceutical industry to promote it or even make it. The patent on Naltrexone has expired. Thank you for getting the word out to more people. It can’t hurt you, so why not try it. But stick with it for a while as I found that it took a while to get used to each new dose increase and had a few side effects in the beginning. Now I really have none except waking up about 4 hours after taking it – I get up and go to the bathroom and go back to bed. A small price to pay for all the relief I get. Plus, I must admit that I do have a better mood and wake up “raring to go”.
    Thank you again for bring this to the attention of more people.

  56. Annmarie January 5, 2015 at 9:27 pm - Reply

    Hi there, I have chronic fatigue as a side effect of a severe hormone imbalance. I am on hydrocortisone as a cortisol HRT. Are you saying that LDN could replace the hydrocortisone or can it be used in conjunction with this? regards Annmarie

    • Suzy Cohen January 7, 2015 at 10:36 pm - Reply

      No I didn’t say that. LDN does not replace hydrocortisone or cortisol, it raises endorphins which are entirely different. Namaste 😉

  57. Susan Meyer January 5, 2015 at 11:47 pm - Reply

    I have lupus and MS and very interested in this medication

    • Nancy March 7, 2015 at 3:48 pm - Reply

      I have Raynaud”s RA osteoarthritis and Lupus would like to know how naltrexone can help me

  58. Watona January 6, 2015 at 12:42 am - Reply

    Can someone take low dose LDN if they’re being treated with antidepressants and Xanax for major depression and panic disorder?

    Thank you.

    • Suzy Cohen January 7, 2015 at 10:32 pm - Reply

      Dear Watona
      Thank you for this excellent question. I would think raising endorphins (our happy brain chemicals) would be indicated for a patient with depression and panic disorders, however, this is a good question to ask the doctor that is treating these conditions. It’s up to him/her not me.

      • LDNNow January 22, 2015 at 11:53 pm - Reply

        yes LDN can be taken in combination with antidepressants – there is currently a clinical trial being held. However it is now being discovered that inflammation is at the root cause in 75% of patients living with depression. By benefitting from the rebound effect where the upregulated levels of the body’s met enkephalin (OGF) by taking LDN serves as a potent anti inflammatory.

    • Amanda February 3, 2015 at 11:57 pm - Reply

      The only drug that cannot be taken with it is an opiate.

  59. Sandra January 6, 2015 at 1:27 am - Reply

    Sorry, but LDN did not work for me, not even after 3 different
    Trials, actually my pain was even worse on LDN!


  60. Robin January 6, 2015 at 2:11 am - Reply

    Can this drug be taken with methotrexate?

  61. Jacquie January 6, 2015 at 7:12 am - Reply

    My brother gave LDN a go hoping it would help him (he has variious autoimmune problems) but unfortunately found that it made his depression worse. Any advice ?

    • LDNNow January 22, 2015 at 11:55 pm - Reply

      That can have an effect if the dose taken is too high – you only want to block the receptors with LDN for 4 hours allowing 20 hours for the good things to happen – increase endorphins and enkephalins

  62. young ki shim January 6, 2015 at 8:25 am - Reply

    thanks for your good information

  63. Brad January 6, 2015 at 2:20 pm - Reply

    Hello, I was curious as to why the lower dose seems to yield a better result yet I have read that generally you work up to a max of 4.5mg. I am sure since everyone is different you have to find that happy medium but just curious why that’s the case.

    • Suzy Cohen January 7, 2015 at 10:44 pm - Reply

      Hi Brad
      The lower doses just ‘tickle’ the receptor. Just enough for your body to look around and say, “Hmmm, not enough endorphins are here, let me start making some for you!”
      Higher doses will completely block the receptors and you won’t get that signal.
      I mean… it’s a little more complicated than this but that’s the gist.
      We are seeing emerging research and anecdotal evidence now that even 1.5 or 3 mg is enough, you have to see what is right for you.

      • Brad January 20, 2015 at 7:08 pm - Reply

        Thank you so much for your response. I struggle with an autoimmune condition similar to lichen planus and have found LDN extremely helpful in combatting my inflammation. I started at 1.5mg and immediately saw an improvement, and on the advice of my doctor increased to 3mg and then to 4.5mg. I had been sitting at 4.5mg for about 6 months with good results, but all of a sudden I noticed that I started getting flares again and my doctor sent me to this page indicating that I might need LESS which I was floored by because that goes against what we’re used to doing. haha. But I have since cut my dose in half and noticed that it DOES help! I have noticed that I am still not as clear as I would like and continuing to get some inflammation. I think I will reduce to half of what I am doing now and see if that continues the trend.

  64. al treichel January 6, 2015 at 3:11 pm - Reply

    will it help with shingles

    • Laura January 9, 2015 at 2:06 pm - Reply

      Al- In the book Primal Panacea, by Thomas Levy MD – he states that Liposomal Vitamin C will elliminate shingles in 24 hours. I have taken this product from LivOn Labs for the past 4 years. It has been a miricle for me. I suggest you read for yourself and order immediately! Shingles are a NIGHTMARE! Good luck!
      ( PS I have tried “other” brands and none have worked. )

  65. Dale Read January 6, 2015 at 4:49 pm - Reply

    I have been taking 4.5 mg of LDN for about three weeks, so far I haven’t really noticed a difference in pain levels. I have three herniated discs in my neck and have Wegener’s in remission for about twelve years now. I’m going to keep using it for at least another month in hopes it kicks in. I’ve tried just about everything else, Cymbalta, Lyrica, epidural injections, physical therapy, hydro condone. Nothing seems to help. Have not worked in two years. If you can give any other advice, will accept it with most gratitude! Thanks.

    • Elizabeth February 14, 2015 at 7:11 pm - Reply

      Dale, as you know, we people with Chronic pain have to try & try & try ’til we find something that works for us.
      Have you ever tried spinal injections? They help me with a lot of my pain. I am put to sleep. I am injected with lidocaine in my spine. I am put to sleep. After I wake up, I am fed a snack parentheses woo hoo! Parentheses closed then I am driven home. That can be repeated every four months.
      Second, Dale, have you tried this combination gabapentin and Cymbalta I noticed you have tried Cymbalta. Have you tried that combination? I tried, several years ago, Gabapentin it did not work for me a friend asked me what anti-INT medicine I was taking at the time I told her Lexapro. Fast forward for years later. My friend asked me if I was still takingLexapro. I said no, I now take Cymbalta. She explained to me that my brain is different now, and I should try gabapentin again. I did, and it works. That is why I am encouraging you to possibly try The combination of Cymbalta and gabapentin.

  66. Khali January 6, 2015 at 7:12 pm - Reply

    hi, i have Hashimoto’s but are not taking medication although i feel terrible and has seen seven endocrinologists and none has help. I am going to try T3 on my own after reading STTM and Recovering with T3 to see if it helps, i have high rt3 and low ft3, has never have high TSH, but i feel horrible mainly it affects my cardiovascular system and i always feel like a tight chest and skip beats, moderate fast rate althought i have had SVT (supraventricular taquichardia) and it has gone to 198 my heart rate. My hair if falling out in bunches, have low Ferritin (34) i am taking iron for it, starting to get arthritis and my two thumbs are like a bit swollen in the bones. Been like this for a year almost house bound and crying a lot because i feel so bad and can’t do nothing that i used to do, i was a very active person taking aerobic classes, riding MTB, skiing, etc, it is very frustrating. Do you thind one can take LDN if i am taking T3? Thank you

    • Suzy Cohen January 7, 2015 at 10:27 pm - Reply

      Dear Khali
      It is nice to meet you hear.
      Here is an e-hug 🙂
      You have been through a lot.
      I just made up a saying… it goes like this, “If you see 7 different endocrinologists, who were all educated the same way, using standard conventional tactics, you will get the same advice 7 times, and that doesn’t make it right!”
      You need to get out of the box, and find someone that thinks differently. Try looking on or
      Yes, people who take T3 can take LDN, that is not abnormal. Happens all the time.
      T3 supports thyroid.
      LDN supports immunity.
      LDN helps with thyroid immunity, it’s actually a good combination… and a good endoctrinologist will know that 😉

  67. John Lee January 6, 2015 at 8:41 pm - Reply

    Can this be taken with an opiate?

    • Suzy Cohen January 7, 2015 at 10:46 pm - Reply

      There’s a LOT of debate on this.
      Currently, if you take it with an opiate, you render your opiate ineffective.
      But there’s a drug company that’s trying to combine LDN with an opiate, in some kind of dosage that makes sense (it’s in testing, I don’t know what they are doing)… but anyway, I would say not to take it together. Wait 4 hours between your LDN and the opiate or you throw your opiate away. That’s just my humble opinion. Please write back and tell me what you notice if you do choose to take it together. I’m curious.

      • JeannieCaroline January 8, 2015 at 8:21 pm - Reply

        is there no EBR to show what happens? I have CRPS and I am on opiates.

  68. Julie January 6, 2015 at 9:52 pm - Reply

    Hi, Suzy,
    I have been on LDN for a couple of years hoping that it would keep my Hashimotos from turning to cancer. I can’t tell any difference in the way that I feel, though. I used to take it at night but now take it in the morning since I already have trouble sleeping. Should I be feeling any different than before I started on it?

  69. Mary chapman January 6, 2015 at 10:34 pm - Reply

    Would this help with mctd & arthritis (osteo)

  70. irene January 6, 2015 at 11:23 pm - Reply

    Is it beneficial for ankylosing spondylitis too?

    • Suzy Cohen January 7, 2015 at 10:20 pm - Reply

      Yes according to the information site, LDN can be beneficial for a host of disorders including Behcet’s disease, CREST syndrome, Crohn’s, Myasthenia Gravis and the one you’ve asked about, ankylosing spondylitis. (I’m sorry you are having to deal with this, here’s a hug).

  71. Linda January 6, 2015 at 11:37 pm - Reply

    Hi, thanks for all the info.
    Can you comment on whether LDN has a time limited application?
    Does it eventually stop working?
    Or if you decided to STOP use would symptoms return, could they be exaccerbated by starting and stopping LDN usage?
    Your comments would be greatly appreciated.
    Cheers from Austalia

    • Suzy Cohen January 7, 2015 at 10:17 pm - Reply

      This is just my opinion, but yes, I think it can stop working all of a sudden for people.
      A lot of debate on this, but again I definitely have heard over and over, that it worked great and then stopped working. I’m not sure what the solution is, other than to give your body a break from it, for a few months, and then restart. Of course, all undertakings are done with your physician’s blessings and approval.

  72. Loretta Norris January 7, 2015 at 12:17 am - Reply

    Have been on 3mg LDN for 7 weeks. I have RA. My out look on life is better, but no physiological improvement or reduction in pain has been noted. I am awaiting results of a U/A for micotoxins, not sure of spelling.

  73. Rebecca January 7, 2015 at 12:47 am - Reply

    Has ldn been used for toxic injury and environmental illness? I have mthfr and il-a polymorphisms and the most difficult health issue is escalating neurotoxicity to mold and now other triggers.

    • Suzy Cohen January 7, 2015 at 10:13 pm - Reply

      Hi Rebecca
      Thank you for your question. LDN doesn’t treat mold. It’s used to help with natural immune function and raise endorphins. I don’t see why it wouldn’t help you, you could certainly try. Hopefully, you’ve heard of Ritchie Shoemaker’s work, on mold. If not, I urge you to go here, he’s the expert:
      Also, please visit my friend, another expert on fungus, Doug Kaufmann,
      Was this helpful?

  74. Kathy January 7, 2015 at 1:55 am - Reply

    Where can I find a dr. that will prescribe the LDN? My two doctors at Kaiser will not give it to me. They say Its only used for drug addiction. They have never heard of giving it at a low dose.

    • Suzy Cohen January 7, 2015 at 10:10 pm - Reply

      Shame on them for not bothering to read about it for 15 minutes! Why don’t you call a compounding pharmacy in your area and ask them who the doctors are that prescribe it, and then make an appointment with that doctor.

  75. Jenna January 7, 2015 at 5:31 am - Reply

    Fibromyalgia was mentioned in the article but not not the list of conditions. Should fibro be on that list? I also have hydromyelia and interstitial cystitis will it work for those too?

  76. Karen Woodring January 7, 2015 at 6:53 pm - Reply

    I have been taking LDN since 2009 and at first it completely gave me my life back due to Fibromyalgia and everything that goes with that…For the last year I can barely tolerate taking it, gives me severe headaches at times and is no longer working and I have no idea what to do…I have decreased the dosage a couple of times and went off of completely for couple of weeks but nothing changes how it affects me now…You have any ideas why? thanks for all your help

    • Suzy Cohen January 7, 2015 at 9:59 pm - Reply

      If you changed pharmacies, they may be making it differently. Sometimes the fillers they use render the naltrexone less active. There are other possibilities but since 2009, it’s possible you changed dispensing pharmacies.

  77. Mette January 8, 2015 at 4:30 am - Reply

    A lot of people with ME/CFS have tried this, with varying results.
    It’s not something that works for most people, but may help some.

  78. Emily Jelassi January 8, 2015 at 8:58 pm - Reply

    Thank you so much for this information! I have CRPS (Complex Regional Pain Syndrome), but didn’t see that on your list above. Would LDN help with my condition?

  79. Amy January 8, 2015 at 9:47 pm - Reply

    Skip’s Pharmacy in Boca Raton, FL is the best compounding pharmacy to use for LDN>

  80. Nancy January 12, 2015 at 9:04 pm - Reply

    I lost my thyroid as it turned cancerous due to undiagnosed Hashimoto’s. I would think it would help Reflex Sympathetic Dystrophy/Complex Regional Pain Sundrome as it is inflammatory. I have had the RSD for 30 yrs and know a lot about it.

    My question is if on a blood test the T cells seem fine, but the NK cells are hardly there at all, if LDN would be recommended ? Thank you.

    • Suzy Cohen January 12, 2015 at 10:22 pm - Reply

      It’s a good question to ask your doctor. I personally think so.

  81. Linley January 13, 2015 at 3:19 pm - Reply

    hi SOOO excited to find you Suzy .Im currently on Tramadole 150mg SR. X3 per day for spine problems but have also been told I have fibromyalgia too ( don’t agree) have been on these drugs for 4 years & still don’t feel good , think they have taken their toll & my body is just unwell now ! I want to get off the Tramadole but tried & my body went into Withdrawl I think ( felt like every nerve in my body was screaming.
    Question is can I drop a dose for a low dose naltrexone & slowly replace naltrexone for Teamadole doses ?
    Thank Linley (Australia)

    • Suzy Cohen January 14, 2015 at 7:45 am - Reply

      You’ll have to be supervised by doc. I’m not sure how to wean you 🙂
      Good for you, for trying though.

  82. David Richardson January 17, 2015 at 2:54 pm - Reply

    Hi Suzy
    Firstly thanks for your article. I use LDN for Sjogrens syndrome to great effect, it has significantly reduced sicca symptoms, fatigue and joint pain……I noticed a few people have been asking if LDN is effective for conditions like CREST and RA. The answer I can give is YES. I run and Faccebook group with over 500 members and I read first hand how LDN is helping people with these conditions.

    ”The purpose of this group is to connect up Low Dose Naltrexone (LDN) user’s who have autoimmune connective tissue diseases and to help those who are thinking about starting LDN by sharing our experiences. We will focus on 4 ‘overlapping’ autoimmune connective tissue diseases: Sjogrens syndrome, Systemic lupus erthematous (SLE), Rheumatoid arthritis (RA) and Scleroderma (CREST & Systemic sclerosis) and investigate how LDN might help. However, also included in the ‘overlap’ are: Mixed Connective Tissue Disease (MCTD), Myositis – Dermatomyositis (DM) + Polymyositis (PM) and Psoriatic arthritis”.

    Here is the link :

    • Suzy Cohen January 18, 2015 at 5:22 am - Reply

      Hello David
      I’ve approved your comment and the link to your facebook… and thank you for the work you are doing for others.

      • David Richardson January 25, 2015 at 7:27 pm - Reply

        Thanks Suzy

        Much appreciated for including the link to our group Suzy. We have gathered now a wealth of experiences.

        And thank you for all the tireless work you do for other’s, and bringing Low Dose Naltrexone (LDN) to the attention of the public.

    • Chloe April 10, 2015 at 7:13 am - Reply

      YESSS! I’ve got EDS! I’ve just requested to join your fb group. awesome.

  83. Bonnie Scot January 18, 2015 at 4:23 am - Reply

    As a fibromyalgia patient I have been taking LDN for two years with excellent results, but the first three months I had terrible side effects. My doctor determined that the pharmacy I used was probably compounding the low dose incorrectly, perhaps by trying to divide high dose tablets and/or using inappropriate fillers.Switching to Skip’s Pharmacy in Boca Raton alleviated all the side effects. They make an excellent product.

  84. CeCe Miles January 18, 2015 at 3:31 pm - Reply

    Suzy…I have shared your article with an Addison’s Group, and am planning on sharing with endocrinologist. (Who knows very little about AD, as most of his patients are diabetic). I notice that you do not mention Addison’s in your list of health problems that could benefit. Do you think this would benefit to take LDN, and of course continuing with our life support of hydrocortisone?

    • Suzy Cohen January 18, 2015 at 5:33 pm - Reply

      I do think LDN could help Addison’s but I haven’t the proof, do you? I think Florinef could be a HUGE good player for people with POTS and Addison-like symptoms. Hydrocortisone would still be needed (with LDN) but you’re doctor will know that.

    • RexAnne Coad March 7, 2015 at 4:33 pm - Reply

      CeCe and Suzy I am very interested in learning about LDN and Addisons. CeCe what is your support group that is talking about this. I have antibodies against adrenal glands ( 21-Hydroxylase antibodies) but have not been diagnosed with Addisons yet. Suzy what direction should I be looking at for research to reduce antibodies?

      • Suzy Cohen March 8, 2015 at 2:18 am - Reply

        Gluten and it’s cross-reactive foods (oats, coffee and others) will attack 21 hydroxylase, did you know that. There’s a study about this by Dr. Aristo Vojdani. You can STOP this.

        • RexAnne Coad March 9, 2015 at 3:29 pm - Reply

          I have been gluten free for the last for the last 8 months ,coffee free for 4 weeks. I did Google his name, can you point me to links that would help? Thank you for answering 🙂

          • Suzy Cohen March 10, 2015 at 9:17 pm

   (Array #4 Gliadin Cross-Reactivity)
            Listen to Dr. Tom O’Bryan’s lecture for free, (that is my website by the way, I hosted that event with Dr. Brownstein… we left 3 hours up for free as a public service. Dr. O’Bryan’s lecture is the one on gluten and coffee, and other cross-reactive foods).

  85. Leanna Cymbala January 20, 2015 at 4:18 pm - Reply

    Is LDN a beta blocker? Also wonder if can be taken along with Bee Venom Therapy?

    Thank you.

    • Suzy Cohen January 20, 2015 at 11:38 pm - Reply

      Hi Leanna,
      LDN is not a beta blocker.
      Ask your physician if he minds if you take it with bee venom shots, up to him/her.

  86. tammy January 21, 2015 at 2:07 am - Reply

    Suzy so glad you covered ldn. I have graves and hashimotos. I’ve tried everything i could find thru research. Ldn has bn the only thing thats helped. Feeling more like myself than I have in the last 8 yrs.

  87. Mike January 21, 2015 at 8:54 pm - Reply

    What are your thoughts on using LDN to treat autoimmune diseases like Multifocal Motor Neuropathy(MMN)?

    • Suzy Cohen January 22, 2015 at 1:22 am - Reply

      I feel that LDN is worth a try for any autoimmune disorder, along with other immune system modulators like probiotics and vitamin D. It’s something to ask your doctor Mike, not me because I don’t have your complete history.

  88. Aimee January 23, 2015 at 8:05 am - Reply

    My daughter 7 yrs has Juvenile Dermatomyositis .
    She takes methotrexate , plaquenile , hydrocortisone ( for adrenal insufficency caused by long term high dose prednisolone ) . And some natural sups .. after 4 long yrs shes headed for remission . Would something like this be advised in a preventative measure to help avoid a relapse ?
    Also would this work for nueropathic pain caused by nerve damaged ?
    Aimee from Australia .

  89. Ina January 25, 2015 at 4:10 am - Reply

    All the sites I’ve found on LDN say you have to be off narcotics before you can start this. Is there another protocol for getting on LDN that doesn’t require getting off narcotix?
    What do you do when you have too much pain to be off narcotics?
    Thanks, love your info!

  90. Darlene Rodgers January 31, 2015 at 5:59 pm - Reply

    I have “neuropathy of unknown origins”. This is my diagnosis. I also have celiac which I believe is my root cause behind the neuropathy. If I take a good B complex as well as 100 – 300 mg of benfotiamine and R Lipoic Acid daily, the burning and pain are subdued. I also take L-Glutamine, eating lots of fermented vegetables and take probiotics to help rebuild my gut health. I have two questions here … Will my stores ever be rebuilt so I don’t have to take all of these daily without all symptoms coming back worse than ever? Could LDN be the answer for me?
    I love reading your articles and am in the process in trying to convince my doctor to consider the LDN so whatever information you can give me, would be greatly appreciated!!

    • Suzy Cohen January 31, 2015 at 7:40 pm - Reply

      Hi Darlene
      LDN doesn’t cure neuropathy.
      At some point, depending on how your diet is, and your lifestyle and if you supplement properly, yes you can rebuild your gut and your microbiome to a healthy status. It doesn’t happen overnight.

  91. Johanna February 2, 2015 at 6:32 am - Reply

    Thanks for the work you do to help people!
    I have not been diagnosed, but have several tested food allergies which makes the eczema I’ve had my whole life seem to be caused by histamine intolerance. Does LDN help in this case? Also hypothyroid, taking 60 mg armour and 50 mcg Liothyronine. Thank you!

  92. Jeff February 4, 2015 at 5:56 pm - Reply


    My son is a brain tumor survivor (medulloblastoma) and is currently 14 years old. He is a St. Jude patient and was diagnosed at 8.5 years old. He is currently cancer free but has lots of side effects, the biggest of which are peripheral neuropathy because of the chemo drug vincristine, bladder issues and cognitive issues. His WBC is usually on the lower end because of all the chemo he has done. I have read a lot about LDN. Do you think this would be good for his main issues that I have described? The cognitive issues are because of the whold brain radiation and chemo. He does take Synthroid and Cytomel for his thyroid. Just wanted to get your thoughts on LDN for my son Charlie to help with some of his side effects.

    • Suzy Cohen February 4, 2015 at 7:36 pm - Reply

      Have to ask doc Jeff, sorry that I cannot advise for you.

  93. Michele W February 8, 2015 at 5:16 am - Reply

    I have had Lupus for the last 11years & it’s been miserable. Im 33 now. I just want some relief. A lady I met on a lupus Facebook site told me about this… I am so happy to hear about it but no idea where to begin to get it. I’m from Wisconsin. Any help would be great!

  94. maureen February 9, 2015 at 5:07 pm - Reply

    My son has menieres (for the last two years) he takes high doses of Usana vitamins & vitamin C,Ginko etc
    This appears to have helped some of his symptoms.
    He runs his own business & if stressed the symptoms get worse.
    He is tired a lot & has headaches..we live in England. Would LDN help him & could we get the National Health service or a private doctor to prescribe it?

  95. Fay February 9, 2015 at 6:18 pm - Reply

    Dear Suzy, I am on LDN for an autoimmune polyneuropathy but am trying to educate my various neurologists about it. Would you please share your favorite journal references on the subject?
    Thank you.

  96. Jeffrey February 10, 2015 at 5:54 am - Reply

    Hi Suzy,

    Enjoyable “Drug Mugger” read!

    Now, would Reishi tea provide lasting relief for chronic or “on/off” Nausea for my 89 year old Mother? I am getting tired of doctors giving her their umpteen types of anti nausea medicines over the past three years along with too many antibiotics? Sure be nice to encounter some neat more natural product for this purpose.

    • Suzy Cohen February 10, 2015 at 6:44 pm - Reply

      The taste of it will make her nauseous.
      Keep it simple, maybe some basic probiotics. Nausea is a symptom not a disease in and of itself. Maybe her antibiotics or something she’s eating or lack of enzymes or probiotics. Could be related to GI bug too. There’s a good GI test called “GI Effects” by Genova/Metametrix Labs. Good luck.

  97. Ina C February 15, 2015 at 2:14 am - Reply

    All the sites I’ve found on LDN say you have to be off narcotics before you can start this. Is there another protocol for getting on LDN that doesn’t require getting off narcotics?
    What do you do when you have too much pain to be off narcotics?
    Thanks, love your info!

    • Suzy Cohen February 15, 2015 at 6:13 am - Reply

      Most people on opiates or narcotic pain meds can take LDN if it’s taken away from their medicine by about 4 or even better 6 ours. It’s up to your doc but I know a lot of people who take a small dose of codeine or oxycodone mid-day but then they also take LDN at night-time, like around 9 or 10pm, without interference.

  98. JED February 15, 2015 at 2:54 am - Reply

    Hi Suzy, and thankyou again for all your hard work. I wrote before about LDN, having tried 5 times, on the 1.5 dose….each time having to stop due to a vice like headache which increased until I couldn’t function.
    At your recent advice, I now break open those capsules and take about a 1/3rd. Hope this works. BUT,…it occurred to me that most auto immune people have gut problems. I have, and I have been working with Paleo diet, suppliements, fermented foods etc. for nearly 5 years. I still haven’t ‘cracked’ it! We are often missing enzymes entirely, like me, I was completely devoid of butyrate. Not everyone gets the tests done to find out these things, and they are so individual.

    Anything that goes into my stomach can react, or simply not work at all. For instance.
    I have taken Vit.D with Vit. K for approx. 10 years, only to find that my Vit. D levels were almost non existent. So, not changing brands, I decided to crack open the capsule with my teeth and let the contents absorb through my cheek and tongue. Bingo,……now my levels are fine, the ONLY change being how I took the product.

    This has made me think that it is actually the state of the gut in each person which decides how LDN will work. Therefore, I would love to know from ‘the pharmacist’ whether LDN could be produced in any other form, such as a patch which one could apply say, after dinner and remove before bed! Perhaps made in a very low dose, so it could be increased if necessary just by adding an extra patch. Either that, or something dissolvable in the mouth..

    • Suzy Cohen February 15, 2015 at 6:02 am - Reply

      Fascinating! I’m not aware of any compounding pharmacies that produce LDN in other forms. I know it was tested as a cream but you’d have to see if anyone could make it for you that way. When I read your note, I wondered if you have an FUT2 snp. If you are homozygous for that, you will need bifido bacteria to help absorb nutrients. I wondered if you have enough digestive enzymes or proteolytic enzymes on board.
      SIBO can affect buytrate levels.
      By the way there are supplements of “butyrate” in case you didn’t know.

    • Mimi March 30, 2016 at 5:23 pm - Reply

      Skip’s Pharmacy in FL has a cream.

  99. Pauline Piazza February 20, 2015 at 10:01 pm - Reply

    I am here in your old hometown, Ocala, Fl, lucky enough to have Dr. Douglas Hall as my functional medicine physician. I have RA and take methetrexate. He is treating my leaky gut and I am improving. Feb.1 he started me on LDN and within 2 weeks my inflammation is almost completely gone and my pain level is down to between 0 and 1. Thank you so much for your information. Today I showed your article about LDN to my rheumatologist and he had never heard of it and said he hadn’t seen any studies done to prove the effectiveness. I told him he didn’t need any studies, I am living proof it works! Been following you since I got my copy of the 24 hour Pharmacist at Frank’s Pharmacy. Stay warm out there in Colorado!

    • Suzy Cohen February 20, 2015 at 10:25 pm - Reply

      That is awesome Pauline, nice to meet you 🙂

  100. Mary March 5, 2015 at 12:38 pm - Reply

    I’m taking LDN and Betaine HCL will this cause stomach ulcers like NSAIDs and Betaine do?

    • Suzy Cohen March 6, 2015 at 6:00 am - Reply

      LDN does not hurt the gut lining like NSAIDS, no.

  101. Joe Puleo March 24, 2015 at 1:48 pm - Reply

    Could this help with psoriatic arthritis? I would love to come off methotrexate.

    • lu March 31, 2015 at 9:59 pm - Reply

      Yes LDN can help with psoriatic arthritis

  102. Jen March 25, 2015 at 6:37 pm - Reply

    Have you heard of using this for Alopecia Areata or any other type of alopecia? My doctor has started me on it for this reason and although my hair loss has slowed it has not stopped. I wonder how long it will take or if it will work at all.

  103. Sherry March 30, 2015 at 5:23 pm - Reply

    Hi Suzy,
    I fell on ice in December and fractured L1. Of course it has been extremely painful! The pain is less now and I have tapered down quite a bit on the meds. I am taking about 3, 5mg oxycodones in a 24 hr. period now. While it is not extreme pain like it was it still slows me down a lot….so, I continue so that I can be up and around doing things I need to do. I am wondering what natural things I can try to get completely off the meds ASAP. Do you think LDN would help this pain? Thanks, Sherry

    • Suzy Cohen March 31, 2015 at 3:00 pm - Reply

      You can’t take LDN with oxy.
      Nothing natural really replaces that.
      California Poppy is very very mild, probably wouldn’t even touch it, but it’s an herb sold as a liquid extract. I doubt it would replace your oxy, but I just want you to know about it.
      I would consider an anti-inflammatory, that’s what I would do (either with or without the oxy).
      Boswellia, curcumin or bromelain, take one (or all 3) if doc says okay.

      • Hope July 6, 2015 at 9:06 pm - Reply

        That’s not true. Check out Oxytrex–a combination of Oxy and LDN.

  104. Ken March 30, 2015 at 5:44 pm - Reply

    Any proof or research that this will help Ménière’s disease? Will me ENT prescribe it or can he?

    • Suzy Cohen March 31, 2015 at 2:49 pm - Reply

      You’d have to look on for research. I answer the questions as much as I can, if they’re short 🙂
      In regards to your other question for me, which is not posted… Yes, there’s one of me and about 650 questions coming in per day from all different directions and I can’t answer them all, esp the ones that require a doctor.
      Yes, an ENT can prescribe it but I suspect he/she will not want to since they probably know nothing about it, but yes, they can definitely write the script.

  105. Shelley March 30, 2015 at 6:00 pm - Reply

    When I took LDN, it made me very dysphoric. The things that used to feel good no longer did (like the head massage when I got my hair washed at the salon). I don’t know if this would have gone away eventually if I continued to take it, but it was miserable. After stopping the med, it took a few weeks to feel better. My mom took it, however, and felt great.

  106. Sheila March 31, 2015 at 10:19 pm - Reply

    I took it for only a few days because it increased my pain by a lot. Do you know why that would happen?

    • Chloe April 10, 2015 at 7:06 am - Reply

      What dose did you start on?

    • Louise April 30, 2015 at 7:56 am - Reply

      Hi, Sheila. I too have taken Naltrexone and become worse. I took it for only 3 days, (1.5 mg the first night, then 2 mg for each of the next two nights; and the peripheral neuropathy in my feet is much MUCH worse than it has ever been.

      When they felt worse after the first night, I even refused to believe it. Not wanting to give up, I took the 3rd and last dose before bed last night. Now, here I am, up at 3:00AM, unable to sleep because of the worsening of the neuropathy.

      I had been SO looking forward to taking the Naltrexone to help with all this misery.

      I was poisoned by ciprofloxacin last July (2014). Within a few days of finishing the course of Cipro, an entire cascade of absolutely horrific symptoms began.
      (I was given 1000mg per day for 7 days as a prophylaxis for a possible UTI…..because it was cloudy, not because I was having any symptoms – the culture was negative, but it took the entire week for the doctor to know this and tell me).

      Within just 9 months I was transformed from an extremely healthy woman who had gone to a doctor simply for a health checkup, into a broken old woman who can barely manage to feed herself.

      Cipro-caused peripheral neuropathy is only ONE of the miserable symptoms I was hoping Naltrexone would help. But it has unquestionably made the neuropathy so much worse that it’s intolerable.

      What I would really like to know is why. Why does Naltrexone help so many people, but not me, and not you, Sheila.

      Cipro has caused nearly everything to go wrong with me. I have neuropathy in my hands and feet, My heart pounds, I’m dizzy, forgetful, my digestive system doesn’t work properly, I’m bloated, nauseous, incontinent, my joints and tendons ache, my hair is nearly gone, my skin is dry, saggy and wrinkled due to the rapid disintegration of collagen, my teeth hurt, my eyes are dry and burn, my mouth and throat are dry, and much more.

      I didn’t expect Naltrexone to work miracles – I know that my body can ever be fixed – but I did expect it to help ‘something,’ even if only a little. I’m just so disappointed to find it has made something so much worse.

      I don’t take medications of any kind – I’m too terrified to do so – other than my multivitamins, magnesium and vitamin C, So I’m pretty sure nothing could be interfering with the Naltrexone. Why is it not doing what it’s supposed to do, creating more endorphins? Surely God would have left me at least a couple.

      • Suzy Cohen April 30, 2015 at 6:34 pm - Reply

        Louise I read your post with a heavy heart. Thank you for being the voice of many others who don’t even know what happened to them! I’ve approved this post (and deleted the duplicate). No worries.
        God bless you, and make sure you’re supported on supplements for nerve health and ATP production. It’s a column in and of itself that I’ve yet to write.

      • Mary May 8, 2015 at 6:00 am - Reply

        Hi Louise! I suggest going on the LDN yahoo group for feedback. But sounds like you may have candida in which LDN will NOT help. In nearly all cases when LDN doesn’t help, the person has candida build up. Cipro is an antibiotic. Taking that can always cause yeast build up. I think that’s the problem. After treating then you should get better. I’m sure of it.

      • Sharon May 18, 2015 at 8:25 pm - Reply


        I was also poisoned by CIPRO. I was prescribed it after 2 rounds of Z-Pak did nothing for undiagnosed pseudomonas…..of course the doctor didn’t do a sputum test until after he gave me CIPRO along with contraindicated-with-Cipro inhaled steroids, which didn’t even kill the bug until weeks after I stopped taking it and had to take amoxicillin for the yeast infection I finally got. I was so sick and had been in bed for months and so when I told him I didn’t think people on thyroid medication were supposed to take Cipro and he told me not to “be silly,” I believed him and went ahead and filled the prescription. He could have given me Keflex (a different class of broad spectrum antibiotic) instead, which is recommended over Cipro for that bacteria in the medical literature and by the lab that finally tested my sputum anyway. Shortly after taking the Cipro I got very extreme hypo / myxedema symptoms…..gained 25 lbs. in a couple of weeks as documented in my GP’s office, swelled up like a balloon, hair fell out, return of anxiety and depression, rT3 high out of range and painful feet when just stepping out of bed. I hadn’t reduced my two thyroid meds and I took probiotics at opposite times from the antibiotics throughout.

        It was only after I did a lot of research that I found out I was correct and that Cipro reduces effectiveness of T4 by about 25% and reduces conversion to T3, which I have to take in addition to T4 anyway because of conversion issues. It has taken me 2 years to even BEGIN to get back to my former baseline with my thyroid medication. I had to go off T4 completely and take a lot of T3 to reduce the rT3 and then kind of start all over again trying to figure out a proper balance of my thyroid meds. It’s taken 2 years but one of the first things that went away when I approached getting my FT3 back in the upper quadrant of the range and in an above 20 ratio of rT3 to FT3 was the neuropathy in my feet and legs.

        My new doctor started me at .5 mg of Naltrexone and it’s only now, after a couple of months and me slowly raising it to 2.0 mg that it MAY be starting to work. I’m supposed to bump it up to 3 mg in a couple of weeks. So maybe it would be a good idea for you have a complete thyroid panel including FT3, rT3, FT4 and thyroid antibodies and make sure your FT4 is mid-range or above and FT3 is in the upper quadrant of the range and start very low with Naltrexone. Even before I had the incident with Cipro, if my FT3 wasn’t in the upper part of the range, I had sore feet to the point I cried ouch when stepping on them and painful joints in my knees.

        FYI : a friend sent me an article from the official in-house USAF magazine on Agent Orange Syndrome that posited Cipro (and other antibiotics in that floxacin class) as being a cause of that neurological disorder. Apparently Cipro was giving as a prophylactic for jungle grunge every day to every serviceman or woman (nurses, support staff) of all branches of the military in Vietnam. It’s criminal that is is still being prescribed to anyone who is not already at death’s door and out of options.

      • Heather June 27, 2015 at 1:04 pm - Reply

        I have fibromyalgia and cipro causes me to feel worse also. But one thing I have learned over the last few years is we all need to detox at least every six months. I don’t know if you have thought of that. But, detoxing has helped me.get off all mess and live an almost normal life. (I say this because tour symptoms sound much like mine did. ) once I started detoxing I atarted feeling better. Don’t get me wrong the first time or two was a bugger because you have to go through some of the same symptoms getting toxins out of you as when they went in and got stored in your different areas of your body. But it is very worth it. Please do some research on it and try it. I hope it will help you like it did me. Then maybe the LDN will help…. my recommendation of a good program to follow is Terry Givens Reset your Body. You can read many success stories on it. Including mine. Good luck and I hope this helps.

      • Hope July 6, 2015 at 9:09 pm - Reply

        Sounds like drug-induced histamine intolerance and degranulation of mast cells.

      • Mel March 5, 2016 at 10:13 pm - Reply

        I was poisoned by Bactrim and have many of the symptoms you write about. What I discovered is that it knocked out my thyroid and triggered my gene for Hashimoto’s. I am being treated for low thyroid with NDT and wanted to try LDN to a mange my AI. Sadly, I must have methylation issues because even at .125mg, my joints ache horribly. Within 24 hours of stopping, the pain diminishes. I know it’s me and not the source of LDN as I used the top recommended compounding pharmacy.

        You might try to find a good thyroid doc for testing and if you choose to try LDN, start at very low doses.

  107. John Brossoit March 31, 2015 at 11:27 pm - Reply

    Question. I’ve had RR Ms since 2008 and am fortunate in that I can still walk, work out, cycle too etc etc but I take anti depressants daily and have tried to cut it out completely going cold turkey but that was a big mistake on my part as I was going through the withdrawls big time. I am wondering if LDN would be better for me. Any issues or thoughts on that I would truly appreciate it.

  108. Merina April 1, 2015 at 5:07 am - Reply

    LDN has imoroved my sleep, eliminated the arthritis in my elbows and wrists, and reduced anxiety. I feel great on it, BUT, it doesn’t do anything for my chronic Erythema nodosum. I thought EN was autoimmune and LDN would help. It flares up when I eat nightshade veggies, and is better on a vegan diet, so I assume leaky gut is involved. Trying to heal my gut with colostrum and Transfer Factors. I am at a loss as to what might help EN. Any suggestions would be appreciated as it is extremely painful.

    • Suzy Cohen April 1, 2015 at 7:02 pm - Reply

      Dear Merina
      I don’t know that much about erythema nodosum other than it is associated with a drug reaction to azathioprine (maybe you have been given that?) and also to a disease called sarcoidosis, so hopefully your physician knows that and has evaluated you for this condition. Knowing what drives this symptom is helpful in terms of treatment. Good luck, keep me posted.

  109. Sally Ann Orrin April 1, 2015 at 12:01 pm - Reply

    My husband has had eczema since he was a baby, 64 years. He suffers severe skin nerve pain on his legs, so bad sometimes that he cannot wear any clothing. I think it may be a form of urticaria but it rarely goes away.. Also has asthma, hypothyroidism, kidney problems and the latest is that his cornea’s are thinning, the doctors think this is an auto-immune problem, but he does not have signs of arthritis. He has been treated with strong immuno-suppressants in the past that probably caused the kidney problems.
    I have printed this article and he will show the relevant information to the consultant and GP – maybe, just maybe this could help, it would be so wonderful that he could stay dressed for a while as the nerve pain is the most debilitating.

    • Suzy Cohen April 1, 2015 at 6:59 pm - Reply

      I’m sorry to hear of his suffering Sally, I know how hard that can be for both of you. It sounds like he has systemic inflammation due to something (could be food sensitivity, could be infection, mold, don’t know). I talk about the immune system at length in my Eczema book, now available as a paperback (used to be just kindle). Perhaps there is a clinical pearl in there for you???
      Keep me posted.

  110. Maija Piittari April 2, 2015 at 1:19 pm - Reply

    I’ve run out of my LDN, no doctor will not prescribe it any longer to me.
    My doc never ever even learned, what it was, doesn’t know of it.
    Have had polymyalgia, then subacute thyroiditis+ hyperthyroid, then hypothyroid state.
    I got rid of Prednison with LDN and am in remission by now, but how long?
    Have been without LDN now 3 months, suffering flu by now.
    Could it be possible to get a prescription from there, I live in Finland, Helsinki. Or the LDN itself?
    There are’nt many docs here, who knows this drug. Or will prescribe it to anybody anyway.
    I would appreciate that very much.

    • Suzy Cohen April 2, 2015 at 5:58 pm - Reply

      Dear Maija
      I copied you to an email to Julia Schopick, who wrote a book on this topic, perhaps she knows of a way. You should print out information for doc and leave at her/his office (or switch doctors) if you feel you still need it. It’s not a surprise the Flu is upon you without your LDN (which supports immunity). Good luck.

      • Sarah August 19, 2015 at 8:32 pm - Reply

        I am sooo happy to hear that you consult with Julia!! Great book, great person!! I am still trying to find a doc that has sense enough to rx this for me! 🙂 This is a great site!

  111. Alano Fray April 7, 2015 at 11:52 pm - Reply

    i have a HORRIBLE case of Peripheral Neuropathy which nothing has helped. Bed ridden to often and can’t walk more than 15 minutes BUT he did not have it on your LDN lays. Please help I can’t take it any more.

  112. Louisa April 13, 2015 at 4:50 pm - Reply

    Hi, I have been searching if LDN would affect peripheral artery disease for I have 13 ml blocked & I am trying smoothies as well to help me, would this help, for I am taking LDN for MS.


    • Suzy Cohen April 16, 2015 at 10:23 pm - Reply

      I can’t find any research on that specifically so I’d say no for the time being. It appears to be useful for MS though.

  113. dan April 21, 2015 at 6:15 am - Reply

    Is LDN appropriate for elderly insomnia patient (early 80s) with recent history of multiple sleep and anti-psychotic medications, who shows signs of agitation and aggression?

  114. Fiona May 5, 2015 at 10:02 pm - Reply

    LDN has been a miracle for me. Was Rxed by my D.O. for fibromyalgia pain. It took away about 60% of the pain but worked an absolute miracle for my ulcerative colitis. It is in remission and my colon is more normal than it has been in over 20 years! My Hashimoto’s thyroiditis antibody level has dropped too and hoping it will keep dropping. Thanks LDN!

  115. Fiona May 5, 2015 at 10:03 pm - Reply

    Definitely start very low dose and titrate up slowly. I started at 0.5mg and ended up at 4.5mg only increasing by 0.5mg every week or so.

  116. Elizabeth May 7, 2015 at 2:20 am - Reply

    I’m a RN of over 10yrs & I have SLE, CFS, Sjogren’s, & Antiphospholipid to name a few. I’ve recently started NAET for my autoimmune disorders & I’m extremely hopeful that with time I will be completely cured!! In order to expedite my healing process, I’ve just started seeing an Integrative Medicine physician. He recommended starting me on LDN but I was aprehensive due to my daily use of Oxycontin & Oxycodone to control my severe pain. It looks like I was right to be aprehensive! This doctor is fairly new to LDN & wasn’t sure how being on opiate pain meds would effect the treatment. So I’ve done the research & see that I can’t be on both. I was hoping to wean off my pain meds once the LDN started working but it doesn’t appear that that is possible. I have found some threads regarding using ULDN (Ultra-low dose Naltrexone) to wean off pain meds. Once you’re completely off your pain meds, you’re then able to start regular dosing of LDN to treat your autoimmune diseases. Do you have any experience or knowledge regarding this matter?

    • Margaret May 31, 2015 at 4:50 am - Reply

      This is exactly my problem. I’d be very grateful for advice.

    • Karen January 31, 2016 at 12:04 am - Reply

      I’m reading this a day late after taking my first dose of LDN of 2.5mg and using fentynl patch. I had a very miserable night unfortunately. NP said it would not be an issue. She was so wrong. I too would like to know if using an ultra low dose while reducing opiate would be acceptable. I have Hashimotos and herniated disks which back pain is why I use fentynl. Suzy, do you have any idea if starting .5mg while on opiates is tolerable?

  117. Pam May 19, 2015 at 2:10 am - Reply

    My question is about dosage. I have RRMS, 1 year diagnosed and i asked my neurologist to try LDN because after trying 2 of the DMTs i said no more. He had to look it up, had no experience regarding using it but decided to give it to me anyways. He prescribed me 4.5mg to take right away, no titrate. I have not started it because everything i read says to start .5mg and i am concerned.

    • Suzy Cohen May 19, 2015 at 3:16 am - Reply

      Most doctors titrate. Research that is emerging suggests staying at the lower doses anyway, like 1, 1.5 or even 3mg. I would ask him what to do one more time.

  118. Jill May 26, 2015 at 2:42 am - Reply

    I thank you Suzy Cohen for making a huge difference in my life. I had seen you and heard you before during Summits where I listened to you, and I think you may have been on Doug Kaufman’s Know the Cause show (not sure I saw you there or not)..

    After I received your email with this article in it in January 2014, I figured if you were suggesting this, then I was going to listen to you! I began researching LDN before I was willing to try it for my 37 year battle with Hashimoto’s thyroiditis. The doctors also removed my thyroid gland 37 years ago and it has been a struggle ever since feeling the doctor’s were not properly treating me and were not listening to me. I did finally find a wonderful natural desiccated thyroid medicine (through that I get from Thailand, and for the last year I have been steadily improving on that. But, I wanted to feel even better than my 67 years were giving me. My husband is 70 and very active; I could not keep up with him!

    After researching for 4 months, I ordered LDN. I had some blood-work done first to see if there will be some improvement in any areas after being on LDN for a while. I mix LDN myself very carefully in distilled water and use exacting syringes to measure accurately. I started at 1.5mg. (I now vary between 2.5 and 3mg.). If I don’t sleep well one night, I lower it. If I feel a bit cranky, I raise it to 3 mg.

    Yes, I did have bad insomnia in the first several days, and had one 3D dream, but I still felt better the next day than I would normally feel after insomnia. I had more energy immediately, within 2 days . I have now been using it for 3 weeks and feel more energy, am more cheerful in general, have better focus, my joints in my hands are 90% more pain-free. I don’t sneeze and blow my nose at all any more. I don’t have to get up at night to urinate but once or less. My stamina is greatly improved and I just feel stronger in general.

    I did have some rapid heart-beat, but my blood pressure stayed normal. I read that that can be an effect of adrenalin or thyroid. Actually, it is better already, so the rapid heart-rate lasted about a week. I have lowered my thyroid meds a little bit, but not a whole lot, maybe 15 mg. I am very aware of hypo and hyper-thyroid symptoms and track everything I am doing in a notebook. I take high amounts of thyroid, so am hoping I will be able to lower it more as time goes by.

    So far, I am so grateful I took the risk and tried this. It may be a final brick to put into place to better my health. By the way, I have been also doing other things for months. I eat my home-made cultured vegetables, take probiotic pills, drink Kambucha, Kefir, and have taken diatomaceous earth for the past year. I have been off of gluten for 4 years now. I eat more Paleo than anything else.

    I read in my research that one’s digestion should be pretty good to have the LDN be the most effective. Maybe that is why it is working so well for me. I feel like a new person! I even help my husband weed the garden now!

    Thank you again, Suzy, for having the courage to put out this information. I am so glad I trusted you!

    • Suzy Cohen May 26, 2015 at 7:41 pm - Reply

      Hi Jill
      You’re very sweet and I really can’t take the credit, you have courage and faith and I’m just shining the flashlight. So happy you and your husband get to enjoy more activities together, I truly understand… it’s the little things.

  119. Jill June 4, 2015 at 10:19 pm - Reply

    Hi Suzy,
    I started LDN three days ago for severe nerve pain/CRPS. I’ve had the condition for three years and take a lot of other medications. I had very high hopes for LDN. However, it has made the squeezing pain around my ears, head, neck and face much worse. The dosage I’ve been started at is 4.5 mg per day. It appears I’m going to need to discontinue the medication due to intolerable pain. Do you know of any other non-mainstream medication to treat CRPS? I’ve tried all the other standard medications for the condition.

    Thank you is advance.


    • Suzy Cohen June 5, 2015 at 6:00 am - Reply

      They shouldn’t have started you on 4.5, that’s what you work up to.

  120. PJ June 7, 2015 at 8:55 pm - Reply

    I have all sicca symptoms consistent with Sjogrens with exception of blood/urine tests. I had a “false positive” but after doing a complete battery of auto immune tests along with physicial examination Rheumatologist didn’t believe I have Sjogrens. However sicca symptoms worsening and fatigue is ridiculous. I also suffer with Restless Legs Syndrome and have recently been battling refractory severe major depression disorder because of limited anti-depressants failing since the exacerbate RLS. Anyhow, what about use of LDN for RLS? It’s contrary since it is an opioid antagonist and opiates are the last line of treatment for refractory RLS… Additionally, if I do not have the official Sjogren’s diagnosis and all my sicca symptoms are just sicca symptoms would LDN be an offending Rx to my system?

  121. ahren June 11, 2015 at 3:52 am - Reply

    I have RSD, I have spoken to my pain management doctor and he told me that going on this medication would be a very bad idea.

  122. Renee June 11, 2015 at 12:53 pm - Reply

    Hi Suzy,
    My husband has ulcerative colitis. He was just prescribed 40 mg’s of pred to reduce every 5 days and Lialda. He also takes bisoprolol, atorvastin, 1 aspirin and plavix due to a previous heart attack.
    I looked in your drug muggers book to see what is mugged for Lialda because I’m concerned about his kidneys, and how the predizone will affect his mind.
    I wonder about LDN, biologics, and/or fecal transplant?
    Any suggestions would be appreciated.
    I did start making and giving him kefir. Marshmellow tea, ubiquinol and slippery elm capsules.


  123. Trish June 14, 2015 at 6:00 pm - Reply

    Hi, my mom just sent me this article to show to my cousin – who was recently diagnosed with primary progressive MS. She has a lot of problems already with her left side, balance, sleep issues, etc. I will double check with her on what other medications she’s on but she seems to be getting worse much faster than expected.

    I would love to find her something to prolong her pain and issues so she can get back to a somewhat normal life, I know you said this will help with MS but there are several types, so I wanted to make sure it’s helped with her type before I suggest it. Additionally, is there an approximate time-frame (starting with the low dose and working up) that she might see results by to gauge if it is helping? I appreciate any input from anyone who knows about this type of MS. Thank you!!!!

  124. Rick June 19, 2015 at 11:12 pm - Reply

    I thought LDN had to be taken between 10pm and 2am each day during the body’s natural time of producing endorphins.

    • Suzy Cohen June 20, 2015 at 6:49 am - Reply

      It’s ideal but the bad dreams sometimes prevent proper dosing. Better some than none.

  125. Beth June 22, 2015 at 10:32 am - Reply

    Hi Suzy. Thanks for keeping up with this board.

    I am about to start a low dose of LDN for my severe mold toxicity. The main complaints I have from this disease (been suffering for 3 years) is asthma (I refuse to go on meds ), fatigue, sinus pressure 24/7, and the loss of my looks/metabolism. (I also have anxiety and insomnia). I was in amazing shape before becoming sick. I still train like I used to, but my muscle tone is gone. I weigh the same but my body composition is not what I deserve. Mold obviously affects hormones and protein synthesis, which is why this is happening. I also have a cyst growing on my ovary that bloats my abdomen. I’m physically and emotionally devastated.

    Have you heard of improvement in regards to any of my symptoms?

    P.S: If anyone else is reading this, mold toxicity is NOT the same as candida. They have similarities, but mold is far more damaging to the system, and is brought on by breathing in spores from water damaged buildings.

    • Suzy Cohen June 22, 2015 at 10:55 pm - Reply

      Hi Beth
      I don’t know of anyone with all of your specific symptoms taken together, but I do know that people with some of these symptoms do respond to LDN. All you an do is try. I have a friend who was stricken with mold last year and she is getting better. It takes time, please accept this e-hug, and hold on. It takes time, your body knows how to heal itself, that’s why when you get a cut, you can heal yourself. Your body knows what to do.
      You should visit (you probably know) Ritchi Shoemaker’s site
      Good luck!

  126. Jill June 27, 2015 at 2:12 am - Reply

    Hi Suzy,

    Love all the info and knowledge you share. I have hashimotos and all the wonderful ailments that co.e with raging autoimmune junk. I would like to start LDN but I take 50 mg trazadone at night for insomnia. Can they be taken together?.
    Thank you!!!

  127. Marney June 27, 2015 at 4:22 pm - Reply

    Thank you Suzy for a great article- you’re amazing! Do you think it’s ok to dissolve 2.5 mg capsule in filtered tap water in order to titrate smaller doses? The 2.5 mg at night radically increased insomnia and pain associated with late stage Lyme and babesia.

    Also, I discovered I tested as borderline low for common variable immune deficiency for IgG subclass deficiency and would like to know if LDN can improve my low IgG? Thank you Suzy!!!

    • Suzy Cohen June 28, 2015 at 5:26 am - Reply

      Hi Marney,
      I think I would just pour out some of the capsule (and put it into apple sauce, yogurt, or just water… or another little empty capsule). I’m not sure it would be stable to do it like you want to in the tap water so I’d recommend not doing that.
      LDN definitely causes insomnia and weird dreams, that is normal… means you need a littler dose.
      CVID– I think they use IVIG for that. has all kinds of information, maybe they talk about that.

  128. Beth June 28, 2015 at 1:29 am - Reply

    Thanks for the e-hug Suzy. I just received my bottle if LDN today, and will take my first dose tonight. Ironically, I have made some discoveries on what was making my condition worse (pea protein – only rice and whey for me from now on!). I’ve also been detoxing with a couple new products, so at least I can give this a try as I’m already on the upswing. My only hope is that I don’t have an unusual bad reaction to the drug, and that I feel some type of improvement over the next couple of days. I will keep you and whoever’s reading this posted on my progress.

    PS: I am very familiar with Dr. Shoemaker. However, I have also researched other physicians who are trying to decipher mold toxicity, and it is clear that his treatments are not a guarantee for everyone. I respect him though. We need other doctors to take a stand for victims like myself who are not able to be heard by the medical community.

  129. Philippa Lauzon June 29, 2015 at 6:17 pm - Reply


    I have severe chemo-induced peripheral neuropathy. My symptoms mimic MS so my naturopathy has been treating me as if I have MS. Do you think LDN would help? I have severe numbness and tingling all over my body. Extreme muscle bone and joint stiffness I am going to try and get a prescription to see what happens but would welcome your thoughts.

    • Suzy Cohen July 1, 2015 at 5:03 pm - Reply

      I don’t know what’s right for you. If you read this thread, some people have great results, and others have horrible side effects related to mind/sleep. I can’t say… sorry. Everyone’s response is individual because we are all unique in our genetics and function.

  130. Beth June 30, 2015 at 9:00 am - Reply

    So I’m back already with disappointing news. The LDN has given me side effects in the worst possible way. I am writing this post because I can’t sleep.

    I woke up Sunday terribly depressed. I indeed had those vivid dreams, but could not shake off my negative emotions for two hours. Then came the detox. I was happy to have lots of elimination from my gut – very healthy bowel movements. I soon began to feel great. Not in a euphoric type of way – it was just genuine energy. So I decided to go out dancing. No drinking or drugs, but when I got home I couldn’t sleep. I’ve been through this (ever since the mold toxicity), so I decided to stay up and enjoy the beautiful day. I couldn’t believe how good I still felt.

    So here I am 36 hours later, losing my mind. My body is not shutting down. I keep having panic attacks as I try to fall asleep. None of my herbal relaxers are helping, and I’m afraid to take more than 25 mg of the generic OTC sleep medIcation. I took 1.5 mg of melatonin. I don’t like going over that amount.

    I don’t mean to scare anyone away from this drug, but NOTHING is worth the state of mind I am in right now. If you have in insomnia and are prone to panic attacks, please be careful. So much for LDN’s “virtually no side effects” reputation.

    • Suzy Cohen July 1, 2015 at 5:02 pm - Reply

      Hi Beth- how awful! Sam had that too so he stopped.
      The doses that they give people are often too high. I think 0.5 to 1.5mg is plenty for people and certainly where to start, if not stay! We are all curious how much you were prescribed (in mg)? And how many nights did you take it for?

      • Beth July 3, 2015 at 9:03 am - Reply

        Hi Suzy,

        I really appreciate you continuing this conversation with me. Now that I have a level head, I am looking back on the day after I took it. Aside from the panic from insomnia, I really was great all day. I was prescribed a dose of 1.5 mg, and I only took it that one night.

        Perhaps I can try just taking 1/3 of it. Maybe the 0.5mg (as you mentioned) would benefit me.

        I am curious though, of your thoughts on how endorphins are produced once the drug is stopped. My biggest fear is developing a sort of tolerance, and losing the ability to produce endorphins on my own. Maybe you know of some medical literature that would confirm that can’t happen.

        Also, who is Sam? A fellow poster? I’ll have to look over your blog again.

        • Suzy Cohen July 4, 2015 at 12:17 am - Reply

          Sam is my husband.
          It’s better to make endorphins now if you don’t have them. Taking LDN doesn’t mean you stop.

          • Beth July 6, 2015 at 6:10 am

            I don’t understand. You just said your husband stopped (taking LDN). If I want to stop because my body is having an intolerable reaction to the drug, then I will. I requested info on what would happen if one were to stop, and I see you don’t have any for me. I am only a believer in using pharmaceuticals indefinitely if one cannot find the root of their illness. I know how I got sick, and will continue to find a way to kill the pathogen. Higher endorphin levels may help, but in my case they are not a means to an end.

    • Susan Rose-Trussux March 31, 2016 at 8:32 pm - Reply

      I was ‘floxed’ and have completely lost the ability to sleep. After reading about insomnia and LDN, there’s no way I would take this drug. Thanks.

  131. Teri July 3, 2015 at 2:30 am - Reply

    hi! This is great info! I found a dr that prescribed me the LDN at 4.5 mg for hashi’s. When I was more tired and had more aching than usual, she lowered down to 3.0 mg. same side effects at this dose as well. She won’t prescribe any lower, says that she’s never done that and doesn’t feel it would be effective…. I now cutting the dose myself with distilled water. If the lower dose works and I need more, how do I convince her to lower my dose??

    • Suzy Cohen July 4, 2015 at 12:18 am - Reply

      We just dump out half of the capsule when we want to take half of the 1.5mg capsule. Or we cut tabs in half with a pill splitter. I don’t pester my doctor (or Sam’s) when I want to reduce a dose.

  132. Ed July 3, 2015 at 2:45 pm - Reply

    On March of 2015 I was diagnost with crohn disease. I don’t have any symptom of the illness the only thing that I’m losing is a lot of weight. from 170 on March now on July 2 I’m 140. I don’t know if this is because of the crohn or because of my anxiety or a diet that I just star because of the condition that include glutten free. The Dr. that is treating the crohn gave me some strong medication(Lialda,Useris) and I stop taking them because of the secondary effect. I went to my primary Dr. and tell him about this situation and he prescribe me a Low Dose Naltrexone. I’m very afraid to have it because I don’t have any of the symptom. Do you thing I should tried this medicine. Thanks!!!!

    • Suzy Cohen July 4, 2015 at 12:16 am - Reply

      I don’t know Ed, I’m not sure why you’re losing weight either, like you said it could be the Crohn’s, the anxiety or a diet (or other). You should ask him to test you. You can also test yourself by ordering your own GI stool test and I recommend Comprehensive Stool Analysis w/Parasitology x1-DD KIT. Just click on that link.

      • Edwin Toro July 4, 2015 at 12:29 pm - Reply

        Hi, thanks for the advise, I already have almost all test done and everyone come good.
        My Dr. prescribed me a Low dose Naltrexone to treat the crohn. When I went to pick it up, the tablet at the pharmacy was for 50mg each. To take 1 tab at bedtime for one week then 2 tabs at bedtime for 1 week then 3 tables at bedtime thereafter. I believe that he gave me a high dose and not the low dose. I was checking for the low dose and they star at 1.5mg to 3 and 4.5mg. I talked with the pharmacy and they told me that this tablet only come in 50mg. Can you please advise me about the right dose and what I have to do to get the low dose? Thanks!!!!!!

        • Suzy Cohen July 4, 2015 at 2:49 pm - Reply

          They are misinformed, I hope you did not take that crazy high dose they gave you!
          Please read my article again, the “L” in LDN stands for “low”
          I give practitioners and any one reading this article ALL the advice necessary for how to have your doctor prescribe this medicine if he wants to. He made a mistake as you can see, because no one should be taking 50mg (or 100mg !!!!!!) at bedtime for this. The pharmacists are apparently unaware as well. Please have them all refer to this article or to It’s a compounded drug like I’ve explained.

        • Gina August 13, 2015 at 10:40 pm - Reply

          You may mix one 50 mg tab in 50 ml of distilled water and then draw up whatever amount you need in a syringe. Yes, your Doc was wrong, the low doses must be compounded. He gave you high dose script such as an addict would take ( btw, I would have him make clear in your records that this was supposed to be low dose… In my opinion, anyone in the future looking at your records may come to the conclusion you have a drug or alcohol problem) But if all you can get are the 50 mg tabs, then you may do the above. This is actually preferable in my view, as then you may titrate up or down.

  133. Lou Thomas July 5, 2015 at 8:04 am - Reply

    Thanks for introducing this important treatment modality to your audience. The uses for autoimmune conditions that you describe are completely accurate, and so is your description of how endorphins are elevated by LDN; I would only point out that LDN has a second mechanism of action (besides via endorphins) which is probably much more responsible for its efficacy in the treatment of autoimmune conditions.

    That second mechanism is by LDN’s blocking of the toll-like receptors (TLR4) on microglia, a part of the immune system that cleans up damaged cells by destroying them. This inflammatory response is triggered by lipo-polysaccharides (LPS), which attach to TLR4 receptors on microglia, stimulating a destructive response via cytokines, damaging healthy cells in the vicinity, which then produce more LPS, stimulating even more of a response from microglia, and so on.

    By blocking the TLR4 receptors once per day for just a few hours after each small dose is taken, LDN interrupts this feedback loop, calming the immune response and allowing the damaged tissue to heal.

  134. Mike July 14, 2015 at 1:48 pm - Reply

    I am interested in learning more. Could you please cite any scientific study demonstrating effectiveness in the disorders you mentioned?

    • Suzy Cohen July 14, 2015 at 2:36 pm - Reply

      Hi Mike please visit and put the term in, or

  135. leanne nox July 17, 2015 at 8:11 am - Reply

    Hi suzy, ive been on ldn for roughly 7 months.. could you explain as too why my skin now looks like im around 90 years of age… what is it that i can do to rectify this.. testing, foods? Etc…

    • Suzy Cohen July 18, 2015 at 1:18 am - Reply

      No idea, that’s a first. Are you certain it’s from LDN?
      (My go-to skin supplement is always astaxanthin).

  136. Jackie August 3, 2015 at 3:36 pm - Reply

    I have Hashimoto’s, and suffer from muscle weakness and pain…specifically in my hips and legs. Would LDN help with this?

    • Suzy Cohen August 6, 2015 at 4:40 am - Reply

      Not sure, everyone has their own individual response.

  137. Kimberly Hinson August 11, 2015 at 7:31 pm - Reply

    hi. My daughter has Multiple Sclerosis and I have researched LDN and asked her Dr. Repeatedly to let her try it and she refuses to give it. Why would she and where can I take her to where the Dr may prescribe.

    Thank you

    • Suzy Cohen August 12, 2015 at 3:24 am - Reply

      Hi Kimberly
      How come you never ask her why? I couldn’t possibly know her rationale.
      I would call the local compounding pharmacies and ask them which doctors in your area prescribe LDN. Let me know how you make out, I wish you and your daughter well.

    • Gina August 13, 2015 at 11:02 pm - Reply

      Usually the reason a doctor won’t prescribe it is because they don’t know squat about it. You said you researched it, but did you share that same research with her? Don’t expect her to research it on her own, doctors are very busy peeps. On the other hand, if you shared your research, and she still won’t do it, then it may be time to find another doctor.
      I’m my case, not only did my rhuematologist know nothing about it ( which is fine, it’s an old drug, a safe drug and a cheap drug and it’s not what the drug reps are pushing, so not many docs know about it) but she didn’t WANT to learn anything or read any material I tried to share, so her butt was promptly fired. I actually ended up getting it from my primary care physician. At first he was reluctant but he was willing to educate himself, read what I gave him, and then prescribed it. Good luck with this and don’t give up:)

    • Nina Taylor January 31, 2016 at 6:33 pm - Reply

      My specialist got confused because he did not realise I was talking about a much lower dose. Most docs know LDN as a drug used in very high doeses for drug withdrawal. SO make sure she understands you are speaking about 0.5 – 6mg. NOT 50mg! You can also get a prescription from LDN Research UK. They sent me a great pack when I contacted them. x

  138. Michelle August 19, 2015 at 6:42 am - Reply

    I started taking LDN, 4.5mg about 3 months ago for interstitial cystitis. I am desperate. The only thing that helped any was amitryptilline, but the 30lb weight gain, hair loss and terrible dry eyes seemed worse than the pain…at the time, so I went off it and found a doc who agreed to let me try LDN. So far, nothing. I was SO optimistic…if anyone should have gotten a placebo effect it was me! I am nearly bedridden with this. I have considered going back on the amitryptilline for awhile and giving the LDN more time to work…but then I won’t know if it IS working, This constant pain is unbearable, and I just don’t know if I should throw in the towel on the LDN. Have you had any experience in women using LDN for IC, and any idea how long it took for them to get relief, if any?

    IC may or may not be autoimmune, and as I also have celiac, and mine developed after I got a stupid polypropolene bladder sling which is now known to cause autoimmunity to develop. So, I am reasonably certain that in my case at least the IC is autoimmune, which is why I really hoped the LDN might work on two fronts- kicking out the endorphins and stopping the AI response. Any odea if this is just wishful thinking?

  139. Lenny Szubinski August 19, 2015 at 6:09 pm - Reply

    Suzy, could you please elaborate a little more on the side effects if LDN? Thanks.

  140. Lisa Vermeulen August 19, 2015 at 6:19 pm - Reply

    LDN has worked well for me. I have issue’s with Mycotoxin’s and Lyme.

    The above issues with Cipro and Levaquin may have a lot to do with Methalating and the MTHFR C677T SNP. I know that they are nig, no no’s for me. A lot of doctor’s don’t check this out first before prescribing.

  141. Anthony Z. August 19, 2015 at 8:19 pm - Reply

    I am glad I re-read your last paragraph. For some reason, and maybe I am the odd case, my 3 mg dose at bed time was keeping me up most of the night, like a caffeine boost from a Cuban coffee. I reduced the dosage to 1.5 mg and started taking it right after dinner. This helped quite a bit as far as getting to sleep. Of all the supplements I have tried, and all the meds LDN has worked the best for my neuropathy, joint stiffness (especially in my hands), and fatigue. I do not expect miracles when you are approaching 70 years of age but it feels good to be able to function fairly close to normal. A question I have on LDN is that does this have a cumulative effect in the body or it needs to be taken/replenished daily? Regards, AZ

  142. candice August 19, 2015 at 9:44 pm - Reply

    Are you aware of any improvements in T1DM using LDN? I note other auto-immune conditions are mentioned, but not diabetes – could it possibly assist in preventing further beta-cell destruction or have other benefits for diabetics? Thank you.

  143. Lisa Hallman August 20, 2015 at 8:03 am - Reply

    I have been suffering from various issues. I have been diagnosed with NAFLD, I have psoriasis, major back pain issues, but unidentifiable. I have nausea and pain around my liver area, but my GB has been removed. I am curious if you think LDN will help with the pain issues, even if cause is unidentified. I also suffer from anxiety and depression. It sucks my energy away so bad.

  144. Yessi August 21, 2015 at 6:23 pm - Reply

    Suzy, I am so curious to try LDN. A lot of my research in autoimmunity and pain leads me to it. Hashimotos is one thing that confuses me because I don’t know when it is better to treat it as an autoimmune disease, and when to treat it as a thyroid disease. I reason that starting with thyroid meds would boost metabolism and that from there, a lot of other things would fall into place. However, maybe LDN is a better starting point. What do you think?
    Best, Yessi

    • Beverley March 22, 2016 at 8:10 pm - Reply

      Hi, I have Hashimotos and nothing helped except LDN. It has given me back my energy and actually, my life. Do try it.

  145. Nadia August 22, 2015 at 4:10 am - Reply

    My doctor started me at 4 mg of naltrexone for cfs should I ask for a lower dose. I have only been on it a week.

    • Suzy Cohen August 23, 2015 at 1:54 am - Reply

      I would, that is a big dose to start with. The correct method is to titrate upward from 1 or 1.5mg.

  146. Joe February 9, 2016 at 11:17 am - Reply

    Suzy, you are an angel for sharing this amazing information that most doctors don’t or won’t share. You have and will change many lives.

    Thank you!!

  147. Laurie April 7, 2016 at 12:13 pm - Reply

    Thank you for all the wonderful suggestions! So far, I understand that my anti phospholipid syndrome is testing high in IL4 and Inf-y. I read these are on both sides of the Th1/Th2 immune response. so, supplements to balance may not be as good as increasing th3 or dampening both sides of that seesaw. Yet, the Th1 is still probably the more dominant in this syndrome. I considered astaxathin because Pubmed showed it is a th2 stimulator and I thought it may help get the vitamins into the cells (I am deficient in fat soluble vitamins) In searching all,of this I ran into the likelihood I have low Tregs and the system is just not turning off. I experience lots of neurological symptoms with the antiphospholipids. Do you see any cautions for me with the LDN? In the list of disorders above, it contains both th1 and th2 dominant disorders, so does the LDN help dampen both sides rather than shift the balance? I am hoping to reduce the inflammation from autoimmune and repair the nerves. It sounds like the LDN may help.

    • Suzy Cohen April 10, 2016 at 11:38 pm - Reply

      There’s no way for me to know the answer to this.
      Worth a try.

  148. martin April 11, 2016 at 4:55 pm - Reply

    I was diagnosed with a small amount of prostate cancer. I tried LDN, 4mg. for about 4 months
    and then had another biopsy. The cancer was gone and my PSA went from 8 to 2. I am a believer!
    I now take 2mg,daily and it helps with depression and I have more energy!

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